IL31RA cdna clone
IL31RA cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Uniprot Description
IL31RA: Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity. Defects in IL31RA are the cause of amyloidosis primary localized cutaneous type 2 (PLCA2). PLCA2 is primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 12 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5q11.2
Cellular Component: plasma membrane
Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity
Biological Process: cytokine and chemokine mediated signaling pathway; JAK-STAT cascade; monocyte differentiation; positive regulation of cell proliferation; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat5 protein
Disease: Amyloidosis, Primary Localized Cutaneous, 2
Research Articles on IL31RA
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Product Notes
The IL31RA il31ra (Catalog #AAA1277042) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGACATACT GGAGATTAGA GAACATAGCG AAAACTGAAC CACCTAAGAT TTTCCGTGTG AAACCAGTTT TGGGCATCAA ACGAATGATT CAAATTGAAT GGATAAAGCC TGAGTTGGCG CCTGTTTCAT CTGATTTAAA ATACACACTT CGATTCAGGA CAGTCAACAG TACCAGCTGG ATGGAAGTCA ACTTCGCTAA GAACCGTAAG GATAAAAACC AAACGTACAA CCTCACGGGG CTGCAGCCTT TTACAGAATA TGTCATAGCT CTGCGATGTG CGGTCAAGGA GTCAAAGTTC TGGAGTGACT GGAGCCAAGA AAAAATGGGA ATGACTGAGG AAGAAGCTCC ATGTGGCCTG GAACTGTGGA GAGTCCTGAA ACCAGCTGAG GCGGATGGAA GAAGGCCAGT GCGGTTGTTA TGGAAGAAGG CAAGAGGAGC CCCAGTCCTA GAGAAAACAC TTGGCTACAA CATATGGTAC TATCCAGAAA GCAACACTAA CCTCACAGAA ACAATGAACA CTACTAACCA GCAGCTTGAA CTGCATCTGG GAGGCGAGAG CTTTTGGGTG TCTATGATTT CTTATAATTC TCTTGGGAAG TCTCCAGTGG CCACCCTGAG GATTCCAGCT ATTCAAGAAA AATCATTTCA GTGCATTGAG GTCATGCAGG CCTGCGTTGC TGAGGACCAG CTAGTGGTGA AGTGGCAAAG CTCTGCTCTA GACGTGAACA CTTGGATGAT TGAATGGTTT CCGGATGTGG ACTCAGAGCC CACCACCCTT TCCTGGGAAT CTGTGTCTCA GGCCACGAAC TGGACGATCC AGCAAGATAA ATTAAAACCT TTCTGGTGCT ATAACATCTC TGTGTATCCA ATGTTGCATG ACAAAGTTGG CGAGCCATAT TCCATCCAGG CTTATGCCAA AGAAGGCGTT CCATCAGAAG GTCCTGAGAC CAAGGTGGAG AACATTGGCG TGAAGACGGT CACGATCACA TGGAAAGAGA TTCCCAAGAG TGAGAGAAAG GGTATCATCT GCAACTACAC CATCTTTTAC CAAGCTGAAG GTGGAAAAGG ATTCTCCAAG ACAGTCAATT CCAGCATCTT GCAGTACGGC CTGGAGTCCC TGAAACGAAA GACCTCTTAC ATTGTTCAGG TCATGGCCAG CACCAGTGCT GGGGGAACCA ACGGGACCAG CATAAATTTC AAGACATTGT CATTCAGTGT CTTTGAGATT ATCCTCATAA CTTCTCTGAT TGGTGGAGGC CTTCTTATTC TCATTATCCT GACAGTGGCA TATGGTCTCA AAAAACCCAA CAAATTGACT CATCTGTGTT GGCCCACCGT TCCCAACCCT GCTGAAAGTA GTATAGCCAC ATGGCATGGA GATGATTTCA AGGATAAGCT AAACCTGAAG GAGTCTGATG ACTCTGTGAA CACAGAAGAC AGGATCTTAA AACCATGTTC CACCCCCAGT GACAAGTTGG TGATTGACAA GTTGGTGGTG AACTTTGGGA ATGTTCTGCA AGAAATTTTC ACAGATGAAG CCAGAACGGG TCAGGAAAAC AATTTAGGAG GGGAAAAGAA TGGGTATGTG ACCTGCCCCT TCAGGCCTGA TTGTCCCCTG GGGAAAAGTT TTGAGGAGCT CCCAGTTTCA CCTGAGATTC CGCCCAGAAA ATCCCAATAC CTACGTTCGA GGATGCCAGA GGGGACCCGC CCAGAAGCCA AAGAGCAGCT TCTCTTTTCT GGTCAAAGTT TAGTACCAGA TCATCTGTGT GAGGAAGGAG CCCCAAATCC ATATTTGAAA AATTCAGTGA CAGCCAGGGA ATTTCTTGTG TCTGAAAAAC TTCCAGAGCA CACCAAGGGA GAAGTCTAA. It is sometimes possible for the material contained within the vial of "IL31RA, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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