DPPA3 cdna clone
DPPA3
Translation Sequence: MDPSQFNPTY IPGSPQMLTE ENSRDDSGAS QISSETLIKN LSNLTINASS ESVSPLSEAL LRRESVGAAV LREIEDEWLY SRRGVRTLLS VQREKMARLR YMLLGGVRTH ERRPTNKEPK GVKKESRPFK CPCSFCVSNG WDPSENARIG NQDTKPLQP
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that in mice may function as a maternal factor during the preimplantation stage of development. In mice, this gene may play a role in transcriptional repression, cell division, and maintenance of cell pluripotentiality. In humans, related intronless loci are located on chromosomes 14 and X. [provided by RefSeq, Jul 2008]
Uniprot Description
DPPA3: Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.
Chromosomal Location of Human Ortholog: 12p13.31
Cellular Component: male pronucleus; cytoplasm; female pronucleus; nucleus
Molecular Function: methylated histone residue binding
Biological Process: chromatin modification; embryonic cleavage
Research Articles on DPPA3
Similar Products
Product Notes
The DPPA3 dppa3 (Catalog #AAA200803) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGGACCCAT CACAGTTTAA TCCAACCTAC ATCCCAGGGT CTCCACAAAT GCTCACCGAA GAAAATTCCC GGGACGATTC AGGGGCCTCT CAAATCTCCT CCGAGACGTT GATAAAGAAC CTTAGTAACT TGACTATCAA CGCTAGTAGC GAATCTGTTT CCCCTCTATC GGAAGCTTTA CTCCGTCGAG AGTCTGTAGG AGCAGCAGTC CTCAGGGAAA TCGAAGATGA GTGGCTTTAC AGCAGGAGAG GAGTAAGAAC ATTGCTGTCT GTGCAGAGAG AAAAGATGGC AAGATTGAGA TACATGTTAC TCGGCGGAGT TCGTACGCAT GAAAGAAGAC CAACAAACAA GGAGCCTAAG GGAGTTAAGA AGGAATCAAG ACCATTCAAA TGTCCCTGCA GTTTCTGCGT GTCTAATGGA TGGGATCCTT CTGAGAATGC TAGAATAGGG AATCAAGACA CCAAGCCACT TCAGCCATAA Tr anslation Sequence: MDPSQFNPTY IPGSPQMLTE ENSRDDSGAS QISSETLIKN LSNLTINASS ESVSPLSEAL LRRESVGAAV LREIEDEWLY SRRGVRTLLS VQREKMARLR YMLLGGVRTH ERRPTNKEPK GVKKESRPFK CPCSFCVSNG WDPSENARIG NQDTKPLQP. It is sometimes possible for the material contained within the vial of "DPPA3, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
