DERL1 cdna clone
DERL1 cDNA Clone
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a member of the derlin family. Members of this family participate in the ER-associated degradation response and retrotranslocate misfolded or unfolded proteins from the ER lumen to the cytosol for proteasomal degradation. This protein recognizes substrate in the ER and works in a complex to retrotranslocate it across the ER membrane into the cytosol. This protein may select cystic fibrosis transmembrane conductance regulator protein (CFTR) for degradation as well as unfolded proteins in Alzheimer's disease. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]
Uniprot Description
DERL1: Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, VIMP/SELS, SEL1L, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-VIMP protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with the cytomegalovirus US11 protein. Interacts with NGLY1 and YOD1. Does not bind to EDEM1. Interacts with RNF103. Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR). Ubiquitous. Belongs to the derlin family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Chaperone; Membrane protein, integral; Membrane protein, multi-pass; Endoplasmic reticulum
Chromosomal Location of Human Ortholog: 8q24.13
Cellular Component: endoplasmic reticulum; integral to endoplasmic reticulum membrane; integral to membrane; membrane
Molecular Function: ATPase binding; MHC class I protein binding; protease binding; protein binding; ubiquitin protein ligase binding
Biological Process: ER-associated protein catabolic process; establishment of protein localization; intracellular transport of viral proteins in host cell; positive regulation of protein binding; positive regulation of protein ubiquitination; protein destabilization; protein homooligomerization; response to unfolded protein; retrograde protein transport, ER to cytosol; unfolded protein response
Research Articles on DERL1
Similar Products
Product Notes
The DERL1 derl1 (Catalog #AAA1267047) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtcggaca tcggagactg gttcaggagc atcccggcga tcacgcgcta ttggttcgcc gccaccgtcg ccgtgccctt ggtcggcaaa ctcggcctca tcagcccggc ctacctcttc ctctggcccg aagccttcct ttatcgcttt cagatttgga ggccaatcac tgccaccttt tatttccctg tgggtccagg aactggattt ctttatttgg tcaatttata tttcttatat cagtattcta cgcgacttga aacaggagct tttgatggga ggccagcaga ctatttattc atgctcctct ttaactggat ttgcatcgtg attactggct tagcaatgga tatgcagttg ctgatgattc ctctgatcat gtcagtactt tatgtctggg cccagctgaa cagagacatg attgtatcat tttggtttgg aacacgattt aaggcctgct atttaccctg ggttatcctt ggattcaact atatcatcgg aggctcggta atcaatgagc ttattggaaa tctggttgga catctttatt ttttcctaat gttcagatac ccaatggact tgggaggaag aaattttcta tccacacctc agtttttgta ccgctggctg cccagtagga gaggaggagt atcaggattt ggtgtgcccc ctgctagcat gaggcgagct gctgatcaga atggcggagg cgggagacac aactggggcc agggctttcg acttggagac cagtga. It is sometimes possible for the material contained within the vial of "DERL1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
