Lamin B1 Protein Recombinant Protein | B1 recombinant protein

Recombinant Rat Lamin B1 Protein (His Tag)

Cat. Num. AAA2569438

• Purity: >90% as determined by reducing SDS-PAGE
• Synonyms: Lamin B1 Protein; Recombinant Rat Lamin B1 Protein (His Tag); ADLD; lamin B1; Lamin-B1; LMN; LMN2; LMNB; Lmnb1; LMNB1; MGC111419; OTTHUMP00000159218; B1 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by reducing SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4
• Sequence: Arg387-Met587

• Species: Rat
• Tag: N-His
• Protein Construction: A DNA sequence encoding the Rat Lamin B1 (P70615-1)(Arg387-Met587) was expressed with a polyhistidine tag at the N-terminus.
• Preparation and Storage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.; This product is provided as lyophilized powder which is shipped with ice packs.

SDS-Page

Related Product Information for B1 recombinant protein

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. This gene encodes one of the two B type proteins, B1. Alternative splicing results in transcript variants and a duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD).

NCBI and Uniprot Product Information

• NCBI GI #: 16758782
• NCBI GeneID: 116685
• NCBI Accession #: NP_446357.1
• NCBI GenBank Nucleotide #: NM_053905.1
• UniProt Accession #: P70615
• Molecular Weight: 66,606 Da
• NCBI Official Full Name: lamin-B1
• NCBI Official Synonym Full Names: lamin B1
• NCBI Official Symbol: Lmnb1
• NCBI Protein Information: lamin-B1
• UniProt Protein Name: Lamin-B1
• Protein Family: Light-harvesting protein
• UniProt Gene Name: Lmnb1
• UniProt Entry Name: LMNB1_RAT

NCBI Description

human homolog is a nuclear lamina protein; involved in nuclear stability, chromatin structure and gene expression [RGD, Feb 2006]

Uniprot Description

Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Cellular Component: cytoplasm; lamin filament; membrane; nuclear envelope; nuclear inner membrane; nuclear lamina; nuclear matrix; nuclear membrane; nucleoplasm; nucleus

Molecular Function: phospholipase binding; protein binding; structural molecule activity

Biological Process: apoptosis; neurogenesis; response to antibiotic; response to drug