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COMMD1 cdna clone

COMMD1

Gene Names
COMMD1; MURR1; C2orf5
Synonyms
COMMD1; C2orf5; MURR1; COMMD1 cdna clone
Ordering
For Research Use Only!
Form/Format
Lyophilized
Sequence
Nucleotide Sequence: ATGGCGGCGGGCGAGCTTGAGGGTGGCAAACCCCTGAGCGGGCTGCTGAATGCGCTGGCCCAGGACACTTTCCACGGGTACCCCGGCATCACAGAGGAGCTGCTACGGAGCCAGCTATATCCAGAGGTGCCACCCGAGGAGTTCCGCCCCTTTCTGGCAAAGATGAGGGGGATTCTTAAGTCTATTGCGTCTGCAGACATGGATTTCAACCAGCTGGAGGCATTCTTGACTGCTCAAACCAAAAAGCAAGGTGGGATCACATCTGACCAAGCTGCTGTCATTTCCAAATTCTGGAAGAGCCACAAGACAAAAATCCGTGAGAGCCTCATGAACCAGAGCCGCTGGAATAGCGGGCTTCGGGGCCTGAGCTGGAGAGTTGATGGCAAGTCTCAGTCAAGGCACTCAGCTCAAATACACACACCTGTTGCCATTATAGAGCTGGAATTAGGCAAATATGGACAGGAATCTGAATTTCTGTGTTTGGAATTTGATGAGGTCAAAGTCAACCAAATTCTGAAGACGCTGTCAGAGGTAGAAGAAAGTATCAGCACACTGATCAGCCAGCCTAACTGA

Translation Sequence: MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN
Sequence Length
190
Species
Human
Chromosome Location
2p15
OMIM Reference Number
607238
cDNA Size
573bp
Vector Description
This shuttle vector contains the complete ORF. It is inseted BamH I to Xho I. The gene insert contains multiple cloning sites which can be used to easily cut and transfer the gene and recombination site into your expression vector.
Vector
(puc19-derived cloning vector)
Preparation Before Usage
1. Centrifuge at 7000rpm for 1 minute. 2. Carefully open the vial and add 100ul of sterile water to dissolve the DNA. Each tube contains approximately 10ug of lyophilized plasmid.
Preparation and Storage
Store the plasmid at -20 degree C.
Product Categories/Family for COMMD1 cdna clone

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
COMM domain-containing protein 1 isoform 1
NCBI Official Synonym Full Names
copper metabolism domain containing 1
NCBI Official Symbol
COMMD1
NCBI Official Synonym Symbols
MURR1; C2orf5
NCBI Protein Information
COMM domain-containing protein 1
UniProt Protein Name
COMM domain-containing protein 1
UniProt Gene Name
COMMD1
UniProt Synonym Gene Names
C2orf5; MURR1
UniProt Entry Name
COMD1_HUMAN

NCBI Description

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

Uniprot Description

COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: Cul2-RING ubiquitin ligase complex; nucleoplasm; recycling endosome; cytoplasm; early endosome; cytoplasmic membrane-bound vesicle; endosome membrane; nucleus

Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; copper ion binding; protein homodimerization activity; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis

Research Articles on COMMD1

Similar Products

Product Notes

The COMMD1 commd1 (Catalog #AAA200629) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: Nucleotide Sequence: ATGGCGGCGG GCGAGCTTGA GGGTGGCAAA CCCCTGAGCG GGCTGCTGAA TGCGCTGGCC CAGGACACTT TCCACGGGTA CCCCGGCATC ACAGAGGAGC TGCTACGGAG CCAGCTATAT CCAGAGGTGC CACCCGAGGA GTTCCGCCCC TTTCTGGCAA AGATGAGGGG GATTCTTAAG TCTATTGCGT CTGCAGACAT GGATTTCAAC CAGCTGGAGG CATTCTTGAC TGCTCAAACC AAAAAGCAAG GTGGGATCAC ATCTGACCAA GCTGCTGTCA TTTCCAAATT CTGGAAGAGC CACAAGACAA AAATCCGTGA GAGCCTCATG AACCAGAGCC GCTGGAATAG CGGGCTTCGG GGCCTGAGCT GGAGAGTTGA TGGCAAGTCT CAGTCAAGGC ACTCAGCTCA AATACACACA CCTGTTGCCA TTATAGAGCT GGAATTAGGC AAATATGGAC AGGAATCTGA ATTTCTGTGT TTGGAATTTG ATGAGGTCAA AGTCAACCAA ATTCTGAAGA CGCTGTCAGA GGTAGAAGAA AGTATCAGCA CACTGATCAG CCAGCCTAAC TGA
Translati on Sequence: MAAGELEGGK PLSGLLNALA QDTFHGYPGI TEELLRSQLY PEVPPEEFRP FLAKMRGILK SIASADMDFN QLEAFLTAQT KKQGGITSDQ AAVISKFWKS HKTKIRESLM NQSRWNSGLR GLSWRVDGKS QSRHSAQIHT PVAIIELELG KYGQESEFLC LEFDEVKVNQ ILKTLSEVEE SISTLISQPN. It is sometimes possible for the material contained within the vial of "COMMD1, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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