COMM domain-containing protein 1 (COMMD1) Recombinant Protein | COMMD1 recombinant protein

Recombinant Human COMM domain-containing protein 1 (COMMD1)

Cat. Num. AAA1395123

• Gene Names: COMMD1; MURR1; C2orf5
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: COMM domain-containing protein 1 (COMMD1); Recombinant Human COMM domain-containing protein 1 (COMMD1); COMM domain-containing protein 1; Protein Murr1; COMMD1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 1-190aa; Full Length
• Sequence: AAGELEGGKPLSGLLNALAQDTFHGYPGITEELLRSQLYPEVPPEEFRPFLAKMRGILKSIASADMDFNQLEAFLTAQTKKQGGITSDQAAVISKFWKSHKTKIRESLMNQSRWNSGLRGLSWRVDGKSQSRHSAQIHTPVAIIELELGKYGQESEFLCLEFDEVKVNQILKTLSEVEESISTLISQPN
• Sequence Length: 189

• Species: Homo sapiens (Human)
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

SDS-PAGE

Related Product Information for COMMD1 recombinant protein

Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes . Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1.

Product Categories/Family for COMMD1 recombinant protein

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 22749079
• NCBI GeneID: 150684
• NCBI Accession #: NP_689729.1
• NCBI GenBank Nucleotide #: NM_152516.2
• UniProt Accession #: Q8N668; Q96GS0; B4DFQ4
• Molecular Weight: 48 kDa
• NCBI Official Full Name: COMM domain-containing protein 1
• NCBI Official Synonym Full Names: copper metabolism (Murr1) domain containing 1
• NCBI Official Symbol: COMMD1
• NCBI Official Synonym Symbols: MURR1; C2orf5
• NCBI Protein Information: COMM domain-containing protein 1; protein Murr1; copper metabolism gene MURR1
• UniProt Protein Name: COMM domain-containing protein 1
• Protein Family: COMM domain-containing protein
• UniProt Gene Name: COMMD1
• UniProt Synonym Gene Names: C2orf5; MURR1
• UniProt Entry Name: COMD1_HUMAN

NCBI Description

COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]

Uniprot Description

COMMD1: Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes.

Protein type: Inhibitor

Chromosomal Location of Human Ortholog: 2p15

Cellular Component: nucleoplasm; Cul2-RING ubiquitin ligase complex; recycling endosome; cytoplasm; cytoplasmic membrane-bound vesicle; early endosome; endosome membrane; nucleus

Molecular Function: identical protein binding; phosphatidylinositol-4,5-bisphosphate binding; protein binding; phosphatidylinositol-3,4,5-triphosphate binding; copper ion binding; protein homodimerization activity; phosphatidylinositol-3,4-bisphosphate binding

Biological Process: Golgi to plasma membrane transport; protein transport; transcription, DNA-dependent; positive regulation of protein ubiquitination; inhibition of NF-kappaB transcription factor; regulation of proteasomal ubiquitin-dependent protein catabolic process; plasma membrane to endosome transport; copper ion homeostasis