NCBI Description
This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]
Uniprot Description
Etk: a tyrosine kinase of the Tec family. Activity is required for IL6-induced differentiation. May play a role in the growth and differentiation of hematopoietic cells. May be involved in signal transduction in endocardial and arterial endothelial cells.
Protein type: Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Kinase, protein; EC 2.7.10.2; TK group; Tec family
Chromosomal Location of Human Ortholog: Xp22.2
Cellular Component: cytosol; extrinsic to internal side of plasma membrane
Molecular Function: non-membrane spanning protein tyrosine kinase activity; protein binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity
Biological Process: cell structure disassembly during apoptosis; innate immune response; mesoderm development; NK T cell differentiation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of cell proliferation; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Product Notes
The BMX bmx (Catalog #
AAA1275354) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atggatacaa aatctattct agaagaactt cttctcaaaa gatcacagca aaagaagaaa atgtcaccaa ataattacaa agaacggctt tttgttttga ccaaaacaaa cctttcctac tatgaatatg acaaaatgaa aaggggcagc agaaaaggat ccattgaaat taagaaaatc agatgtgtgg agaaagtaaa tctcgaggag cagacgcctg tagagagaca gtacccattt cagattgtct ataaagatgg gcttctctat gtctatgcat caaatgaaga gagccgaagt cagtggttga aagcattaca aaaagagata aggggtaacc cccacctgct ggtcaagtac catagtgggt tcttcgtgga cgggaagttc ctgtgttgcc agcagagctg taaagcagcc ccaggatgta ccctctggga agcatatgct aatctgcata ctgcagtcaa tgaagagaaa cacagagttc ccaccttccc agacagagtg ctgaagatac ctcgggcagt tcctgttctc aaaatggatg caccatcttc aagtaccact ctagcccaat atgacaacga atcaaagaaa aactatggct cccagccacc atcttcaagt accagtctag cgcaatatga cagcaactca aagaaaatct atggctccca gccaaacttc aacatgcagt atattccaag ggaagacttc cctgactggt ggcaagtaag aaaactgaaa agtagcagca gcagtgaaga tgttgcaagc agtaaccaaa aagaaagaaa tgtgaatcac accacctcaa agatttcatg ggaattccct gagtcaagtt catctgaaga agaggaaaac ctggatgatt atgactggtt tgctggtaac atctccagat cacaatctga acagttactc agacaaaagg gaaaagaagg agcatttatg gttagaaatt cgagccaagt gggaatgtac acagtgtcct tatttagtaa ggctgtgaat gataaaaaag gaactgtcaa acattaccac gtgcatacaa atgctgagaa caaattatac ctggcagaaa actactgttt tgattccatt ccaaagctta ttcattatca tcaacacaat tcagcaggca tgatcacacg gctccgccac cctgtgtcaa caaaggccaa caaggtcccc gactctgtgt ccctgggaaa tggaatctgg gaactgaaaa gagaagagat taccttgttg aaggagctgg gaagtggcca gtttggagtg gtccagctgg gcaagtggaa ggggcagtat gatgttgctg ttaagatgat caaggagggc tccatgtcag aagatgaatt ctttcaggag gcccagacta tgatgaaact cagccatccc aagctggtta aattctatgg agtgtgttca aaggaatacc ccatatacat agtgactgaa tatataagca atggctgctt gctgaattac ctgaggagtc acggaaaagg acttgaacct tcccagctct tagaaatgtg ctacgatgtc tgtgaaggca tggccttctt ggagagtcac caattcatac accgggactt ggctgctcgt aactgcttgg tggacagaga tctctgtgtg aaagtatctg actttggaat gacaaggtat gttcttgatg accagtatgt cagttcagtc ggaacaaagt ttccagtcaa gtggtcagct ccagaggtgt ttcattactt caaatacagc agcaagtcag acgtatgggc atttgggatc ctgatgtggg aggtgttcag cctggggaag cagccctatg acttgtatga caactcccag gtggttctga aggtctccca gggccacagg ctttaccggc cccacctggc atcggacacc atctaccaga tcatgtacag ctgctggcac gagcttccag aaaagcgtcc cacatttcag caactcctgt cttccattga accacttcgg gaaaaagaca agcattga.
It is sometimes possible for the material contained within the vial of
"BMX, cDNA Clone" to become dispersed throughout the inside of
the vial, particularly around the seal of said vial, during shipment and storage. We always
suggest centrifuging these vials
to consolidate all of the liquid away from the lid and to the bottom of the vial prior to
opening. Please be advised that
certain products may require dry ice for shipping and that, if this is the case, an
additional dry ice fee may also be
required.
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