Rabbit INSIG2 Polyclonal Antibody | anti-INSIG2 antibody

INSIG2 Rabbit Polyclonal

Cat. Num. AAA7600567

• Gene Names: INSIG2; INSIG-2
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: INSIG2; Polyclonal Antibody; INSIG2 Rabbit Polyclonal; anti-INSIG2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 97

• Applicable Applications for anti-INSIG2 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Insulin induced gene 2
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human liver tissue slide using MBS7600567 (INSIG2 Antibody) at dilution of 1:50)

Western Blot (WB)

(rat liver tissue were subjected to SDS PAGE followed by western blot with MBS7600567 (INSIG2 Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 1008806550
• NCBI GeneID: 51141
• NCBI Accession #: NP_001308262.1
• NCBI GenBank Nucleotide #: NM_001321333.1
• Molecular Weight: 24,778 Da
• NCBI Official Full Name: insulin-induced gene 2 protein isoform c
• NCBI Official Synonym Full Names: insulin induced gene 2
• NCBI Official Symbol: INSIG2
• NCBI Official Synonym Symbols: INSIG-2
• NCBI Protein Information: insulin-induced gene 2 protein
• UniProt Protein Name: Insulin-induced gene 2 protein
• Protein Family: Insulin-induced gene 2 protein
• UniProt Gene Name: INSIG2
• UniProt Synonym Gene Names: INSIG-2
• UniProt Entry Name: INSI2_HUMAN

NCBI Description

The protein encoded by this gene is highly similar to the protein product encoded by gene INSIG1. Both INSIG1 protein and this protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. [provided by RefSeq, Jul 2008]

Uniprot Description

INSIG2: Mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. Functions by blocking the processing of sterol regulatory element-binding proteins (SREBPs). Capable of retaining the SCAP-SREBF2 complex in the ER thus preventing it from escorting SREBPs to the Golgi. Seems to regulate the ubiquitin-mediated proteasomal degradation of HMGCR. Belongs to the INSIG family.

Protein type: Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2q14.2

Cellular Component: endoplasmic reticulum membrane

Molecular Function: protein binding; transcription factor binding

Biological Process: cholesterol biosynthetic process; inner ear morphogenesis; middle ear morphogenesis; negative regulation of fatty acid biosynthetic process; palate development; response to insulin stimulus; SREBP-mediated signaling pathway; triacylglycerol metabolic process