ASPM cdna clone
ASPM cDNA Clone
Gene Names
ASPM; ASP; MCPH5; Calmbp1
Synonyms
ASPM; ASPM cDNA Clone; ASPM cdna clone
Sequence
atgtctctcagagcttatactgctcggtgtaggttaaacagactacgtcgtgcagcatgccgtttgtttacttctgaaaaaatggttaaagctattaaaaagcttgaaattgaaattgaagctaggcggttaattgttcgaaaagatagacacctatggaaagatgtgggagaacgtcagaaagtcctgaattggctgttgtcctacaatcctttgtggcttcgaattggtctagagacaacttatggagaactcatatctttggaagataacagtgatgtcacagggttggctatgtttattctgaatcgcctactttggaatcctgatatagcagctgagtatagacaccccactgttcctcacctgtatagagatggtcatgaagaagctttgtccaagtttacattgaaaaagttattgttgttggtctgttttcttgattatgctaaaatttccagactcattgatcatgatccttgtctcttctgtaaagatgccgaattcaaggctagtaaagaaatccttttggctttttcacgagatttcctaagtggtgaaggtgacctttcccgtcaccttggcttattgggattacctgttaaccatgttcagacaccatttgatgaatttgattttgccgttacaaatcttgccgtagacttgcaatgtggagtgcgccttgtgcgaaccatggaacttctcacacagaactgggacctctcaaagaaactcaggattccggcaataagtcgtcttcaaaagatgcacaatgttgacattgttcttcaagttcttaaatcacgaggaattgaattaagtgatgagcatggaaatacaattctatctaaggatattgtggataggcacagagaaaaaactctcaggttgctttggaaaatagcgtttgcttttcaggtggatatttcccttaacttagatcaattaaaggaagaaattgcctttctaaaacacacaaagagtataaagaaaacaatatctctactatcatgccattttgatgatcttattaataagaaaaaaggcaaaagggatagtggttcctttgaacaatatagtgaaaacataaagttattgatggattgggtaaatgctgtttgtgccttctataataaaaaggtggagaattttacagtgtctttctcagacggccgtgtgttatgttacctgatccaccattaccatccttgctatgtgccatttgacgctatatgtcagcgtactactcaaactgtggaatgtacgcaaactggttcagtggtattaaattcatcatctgaatctgatgacagttctctggatatgtctcttaaagcatttgatcatgaaaatacttcagagctatacaaagagctcctagaaaatgaaaagaaaaattttcacttggttaggtctgcagttagagaccttggtggaatacctgctatgattaatcattcagatatgtcaaatacaattccagatgaaaaggtggttattacctatttgtcatttctttgtgcaaggcttttggatcttcgtaaagaaataagagctgctcgactcatacaaacaacatggagaaaatataaactaaaaacagatctcaaacgccatcaggagagagagaaagctgcaagaattattcaattggctgtaatcaattttctagcaaaacaaagattgagaaaaagagttaatgcagcactcgtcattcagaaatattggcgaagagtcttagcacagagaaaattattaatgttaaaaaaggaaaagctggaaaaagttcaaaataaagcagcatcacttattcaggctatgtggaggagatatagagccaagaaatatttatgtaaagtgaaagctgcctgcaagattcaagcctggtatagatgttggagagcacacaaagaatatctagctatattaaaagctgttaaaattattcaaggttgcttctataccaaactagagagaacacggtttttgaatgtgagagcatcagcaattatcattcagagaaaatggagagctatacttcctgcaaagatagctcatgaacacttcttaatgataaaaagacatcgagctgcttgtttgatccaagcacattatagaggatataaaggaaggcaggtctttcttcggcagaaatctgctgctttgatcatacaaaaatatatacgagccagggaggctggaaagcatgaaaggataaaatatattgaatttaaaaaatctacagttatcctacaagcactggtgcgtggttggctagtacgaaaaagatttttagaacagagagccaaaattcgacttcttcacttcactgcagctgcatattatcacctgaatgctgttagaattcaaagagcctataaactttacctggctgtgaagaatgctaacaagcaggttaattcagtcatctgtattcagagatggtttcgagcaagattacaagaaaagagatttattcagaaatatcatagcatcaaaaagattgagcatgaaggtcaagaatgtctgagccagcgaaatagggctgcatcagtaatacagaaagcagtgcgccattttctcctccgtaaaaagcaggaaaaattcactagtggaatcattaaaattcaggcattatggagaggctattcttggaggaagaaaaatgattgtacaaaaattaaagctatacgactaagtcttcaagttgttaatagggagattcgagaagaaaacaaactctacaaaagaactgcacttgcacttcattaccttttgacatataagcacctttctgccattcttgaggccttaaaacacctagaggtagttactagattgtctccactttgttgtgagaacatggcccagagtggagcaatttctaaaatatttgttttgatccgaagttgtaatcgcagtattccttgtatggaagtcatcagatatgctgtgcaagtcttgcttaatgtatctaagtatgagaaaactacttcagcagtttatgatgtagaaaattgtatagatatactattggagcttttgcagatataccgagaaaagcctggtaataaagttgcagacaaaggcggaagcatttttacaaaaacttgttgtttgttggctattttactgaagacaacaaatagagcctctgatgtacgaagtaggtccaaagttgttgaccgtatttacagtctctacaaacttacagctcataaacataaaatgaatactgaaagaatactttacaagcaaaagaagaattcttctataagcattccttttatcccagaaacacctgtaaggaccagaatagtttcaagacttaagccagattgggttttgagaagagataacatggaagaaatcacaaatcccctgcaagctattcaaatggtgatggatacgcttggcattccttattag
Sequence Length
3429
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
217,794 Da
NCBI Official Full Name
Homo sapiens asp (abnormal spindle) homolog, microcephaly associated (Drosophila), mRNA
NCBI Official Synonym Full Names
abnormal spindle microtubule assembly
NCBI Official Symbol
ASPM
NCBI Official Synonym Symbols
ASP; MCPH5; Calmbp1
NCBI Protein Information
abnormal spindle-like microcephaly-associated protein
UniProt Protein Name
Abnormal spindle-like microcephaly-associated protein
Protein Family
UniProt Gene Name
ASPM
UniProt Synonym Gene Names
MCPH5; Asp homolog
UniProt Entry Name
ASPM_HUMAN
NCBI Description
This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]
Uniprot Description
ASPM: Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis. Defects in ASPM are the cause of microcephaly primary type 5 (MCPH5); also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1q31
Cellular Component: nucleus
Biological Process: spindle localization; spindle organization and biogenesis
Disease: Microcephaly 5, Primary, Autosomal Recessive
Research Articles on ASPM
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Product Notes
The ASPM aspm (Catalog #AAA7046789) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: atgtctctca gagcttatac tgctcggtgt aggttaaaca gactacgtcg tgcagcatgc cgtttgttta cttctgaaaa aatggttaaa gctattaaaa agcttgaaat tgaaattgaa gctaggcggt taattgttcg aaaagataga cacctatgga aagatgtggg agaacgtcag aaagtcctga attggctgtt gtcctacaat cctttgtggc ttcgaattgg tctagagaca acttatggag aactcatatc tttggaagat aacagtgatg tcacagggtt ggctatgttt attctgaatc gcctactttg gaatcctgat atagcagctg agtatagaca ccccactgtt cctcacctgt atagagatgg tcatgaagaa gctttgtcca agtttacatt gaaaaagtta ttgttgttgg tctgttttct tgattatgct aaaatttcca gactcattga tcatgatcct tgtctcttct gtaaagatgc cgaattcaag gctagtaaag aaatcctttt ggctttttca cgagatttcc taagtggtga aggtgacctt tcccgtcacc ttggcttatt gggattacct gttaaccatg ttcagacacc atttgatgaa tttgattttg ccgttacaaa tcttgccgta gacttgcaat gtggagtgcg ccttgtgcga accatggaac ttctcacaca gaactgggac ctctcaaaga aactcaggat tccggcaata agtcgtcttc aaaagatgca caatgttgac attgttcttc aagttcttaa atcacgagga attgaattaa gtgatgagca tggaaataca attctatcta aggatattgt ggataggcac agagaaaaaa ctctcaggtt gctttggaaa atagcgtttg cttttcaggt ggatatttcc cttaacttag atcaattaaa ggaagaaatt gcctttctaa aacacacaaa gagtataaag aaaacaatat ctctactatc atgccatttt gatgatctta ttaataagaa aaaaggcaaa agggatagtg gttcctttga acaatatagt gaaaacataa agttattgat ggattgggta aatgctgttt gtgccttcta taataaaaag gtggagaatt ttacagtgtc tttctcagac ggccgtgtgt tatgttacct gatccaccat taccatcctt gctatgtgcc atttgacgct atatgtcagc gtactactca aactgtggaa tgtacgcaaa ctggttcagt ggtattaaat tcatcatctg aatctgatga cagttctctg gatatgtctc ttaaagcatt tgatcatgaa aatacttcag agctatacaa agagctccta gaaaatgaaa agaaaaattt tcacttggtt aggtctgcag ttagagacct tggtggaata cctgctatga ttaatcattc agatatgtca aatacaattc cagatgaaaa ggtggttatt acctatttgt catttctttg tgcaaggctt ttggatcttc gtaaagaaat aagagctgct cgactcatac aaacaacatg gagaaaatat aaactaaaaa cagatctcaa acgccatcag gagagagaga aagctgcaag aattattcaa ttggctgtaa tcaattttct agcaaaacaa agattgagaa aaagagttaa tgcagcactc gtcattcaga aatattggcg aagagtctta gcacagagaa aattattaat gttaaaaaag gaaaagctgg aaaaagttca aaataaagca gcatcactta ttcaggctat gtggaggaga tatagagcca agaaatattt atgtaaagtg aaagctgcct gcaagattca agcctggtat agatgttgga gagcacacaa agaatatcta gctatattaa aagctgttaa aattattcaa ggttgcttct ataccaaact agagagaaca cggtttttga atgtgagagc atcagcaatt atcattcaga gaaaatggag agctatactt cctgcaaaga tagctcatga acacttctta atgataaaaa gacatcgagc tgcttgtttg atccaagcac attatagagg atataaagga aggcaggtct ttcttcggca gaaatctgct gctttgatca tacaaaaata tatacgagcc agggaggctg gaaagcatga aaggataaaa tatattgaat ttaaaaaatc tacagttatc ctacaagcac tggtgcgtgg ttggctagta cgaaaaagat ttttagaaca gagagccaaa attcgacttc ttcacttcac tgcagctgca tattatcacc tgaatgctgt tagaattcaa agagcctata aactttacct ggctgtgaag aatgctaaca agcaggttaa ttcagtcatc tgtattcaga gatggtttcg agcaagatta caagaaaaga gatttattca gaaatatcat agcatcaaaa agattgagca tgaaggtcaa gaatgtctga gccagcgaaa tagggctgca tcagtaatac agaaagcagt gcgccatttt ctcctccgta aaaagcagga aaaattcact agtggaatca ttaaaattca ggcattatgg agaggctatt cttggaggaa gaaaaatgat tgtacaaaaa ttaaagctat acgactaagt cttcaagttg ttaataggga gattcgagaa gaaaacaaac tctacaaaag aactgcactt gcacttcatt accttttgac atataagcac ctttctgcca ttcttgaggc cttaaaacac ctagaggtag ttactagatt gtctccactt tgttgtgaga acatggccca gagtggagca atttctaaaa tatttgtttt gatccgaagt tgtaatcgca gtattccttg tatggaagtc atcagatatg ctgtgcaagt cttgcttaat gtatctaagt atgagaaaac tacttcagca gtttatgatg tagaaaattg tatagatata ctattggagc ttttgcagat ataccgagaa aagcctggta ataaagttgc agacaaaggc ggaagcattt ttacaaaaac ttgttgtttg ttggctattt tactgaagac aacaaataga gcctctgatg tacgaagtag gtccaaagtt gttgaccgta tttacagtct ctacaaactt acagctcata aacataaaat gaatactgaa agaatacttt acaagcaaaa gaagaattct tctataagca ttccttttat cccagaaaca cctgtaagga ccagaatagt ttcaagactt aagccagatt gggttttgag aagagataac atggaagaaa tcacaaatcc cctgcaagct attcaaatgg tgatggatac gcttggcatt ccttattag. It is sometimes possible for the material contained within the vial of "ASPM, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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