SDS-Page
(Recombinant Human GFRA1/GFRalpha1/GDNFRA was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 80-95 kDa.)
GFRA1/GFRalpha1/GDNFRA Recombinant Protein | GFRA1 recombinant protein
Recombinant Human GFRA1/GFRalpha1/GDNFRA Protein
Gene Names
GFRA1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
Purity
> 70% by SDS-PAGE.
Synonyms
GFRA1/GFRalpha1/GDNFRA; Recombinant Human GFRA1/GFRalpha1/GDNFRA Protein; GFRA1; GDNFR; GDNFRA; GFR-ALPHA-1; RET1L; RETL1; TRNR1; GFRA1 recombinant protein
Host
HEK293 cells
Purity/Purification
> 70% by SDS-PAGE.
Form/Format
Lyophilized from a 0.22 muM filtered solution of PBS, pH 7.4.
Sequence
AEVSGGDRLDCVKASDQCLKEQSCSTKYRTLRQCVAGKETNFSLASGLEAKDECRSAMEALKQKSLYNCRCKRGMKKEKNCLRIYWSMYQSLQGNDLLEDSPYEPVNSRLSDIFRVVPFISVEHIPKGNNCLDAAKACNLDDICKKYRSAYITPCTTSVSNDVCNRRKCHKALRQFFDKVPAKHSYGMLFCSCRDIACTERRRQTIVPVCSYEEREKPNCLNLQDSCKTNYICRSRLADFFTNCQPESRSVSSCL
Sequence Length
460
Species
Human
Endotoxin
< 0.1 EU/mug of the protein by LAL method.
Tag
Fc, 6xHis tag at the C-terminus
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Protein Construction
High quality, high purity and low endotoxin recombinant Recombinant Human GFRA1/GFRalpha1/GDNFRA Protein (RP00102), tested reactivity in Human and has been validated in SDS-PAGE.100% guaranteed.
Preparation and Storage
Store the lyophilized protein at-20 degree C to-80 degree C for long term.
After reconstitution, the protein solution is stable at-20 degree C for 3 months, at 2-8 degree C for up to 1 week.
After reconstitution, the protein solution is stable at-20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human GFRA1/GFRalpha1/GDNFRA was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 80-95 kDa.)
SDS-Page
(Recombinant Human GFRA1/GFRalpha1/GDNFRA was determined by SDS-PAGE under reducing conditions with Coomassie Blue, showing a band at 80-95 kDa.)
Related Product Information for GFRA1 recombinant protein
Description: Recombinant Human GFRA1/GFRalpha1/GDNFRA Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ala19-Lys429) of human GFRA1/GFRalpha1/GDNFRA (Accession #NP_665736) fused with an Fc, 6xHis tag at the C-terminus.
Background: This protein is a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
Background: This protein is a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI) -linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
50,838 Da
NCBI Official Full Name
GDNF family receptor alpha-1 isoform b
NCBI Official Synonym Full Names
GDNF family receptor alpha 1
NCBI Official Symbol
GFRA1
NCBI Official Synonym Symbols
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
NCBI Protein Information
GDNF family receptor alpha-1
UniProt Protein Name
GDNF family receptor alpha-1
Protein Family
UniProt Gene Name
GFRA1
UniProt Synonym Gene Names
GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1
NCBI Description
This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Uniprot Description
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor ().
Research Articles on GFRA1
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Product Notes
The GFRA1 gfra1 (Catalog #AAA9139699) is a Recombinant Protein produced from HEK293 cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: AEVSGGDRLD CVKASDQCLK EQSCSTKYRT LRQCVAGKET NFSLASGLEA KDECRSAMEA LKQKSLYNCR CKRGMKKEKN CLRIYWSMYQ SLQGNDLLED SPYEPVNSRL SDIFRVVPFI SVEHIPKGNN CLDAAKACNL DDICKKYRSA YITPCTTSVS NDVCNRRKCH KALRQFFDKV PAKHSYGMLF CSCRDIACTE RRRQTIVPVC SYEEREKPNC LNLQDSCKTN YICRSRLADF FTNCQPESRS VSSCL. It is sometimes possible for the material contained within the vial of "GFRA1/GFRalpha1/GDNFRA, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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