Vector Map
ALOX15B cdna clone
Human ALOX15B cDNA Clone
Vector Map
Vector Map
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Description
ALOX15B: Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Belongs to the lipoxygenase family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation; Oxidoreductase; Lipid Metabolism - arachidonic acid; Motility/polarity/chemotaxis; EC 1.13.11.33; Apoptosis
Chromosomal Location of Human Ortholog: 17p13.1
Cellular Component: cytoplasm; cytoskeleton; cytosol; extrinsic to membrane; intracellular; membrane; plasma membrane
Molecular Function: arachidonate 15-lipoxygenase activity; calcium ion binding; iron ion binding; lipoxygenase activity
Biological Process: apoptosis; arachidonic acid metabolic process; hepoxilin biosynthetic process; lipid metabolic process; lipoxygenase pathway; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of growth
Research Articles on ALOX15B
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Product Notes
The ALOX15B alox15b (Catalog #AAA1268594) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCCGAGT TCAGGGTCAG GGTGTCCACC GGAGAAGCCT TCGGGGCTGG CACATGGGAC AAAGTGTCTG TCAGCATCGT GGGGACCCGG GGAGAGAGCC CCCCACTGCC CCTGGACAAT CTCGGCAAGG AGTTCACTGC GGGCGCTGAG GAGGACTTCC AGGTGACGCT CCCGGAGGAC GTAGGCCGAG TGCTGCTGCT GCGCGTGCAC AAGGCGCCCC CAGTGCTGCC CCTGCTGGGG CCCCTGGCCC CGGATGCCTG GTTCTGCCGC TGGTTCCAGC TGACACCGCC GCGGGGCGGC CACCTCCTCT TCCCCTGCTA CCAGTGGCTG GAGGGGGCGG GGACCCTGGT GCTGCAGGAG GGTACAGCCA AGGTGTCCTG GGCAGACCAC CACCCTGTGC TCCAGCAACA GCGCCAGGAG GAGCTTCAGG CCCGGCAGGA GATGTACCAG TGGAAGGCTT ACAACCCAGG TTGGCCTCAC TGCCTGGATG AAAAGACAGT GGAAGACTTG GAGCTCAATA TCAAATACTC CACAGCCAAG AATGCCAACT TTTATCTACA GGCTGGCTCT GCTTTTGCAG AGATGAAAAT CAAGGGGTTG CTGGACCGCA AGGGGCTCTG GAGGAGTCTG AATGAGATGA AAAGGATCTT CAACTTCCGG AGGACCCCAG CAGCTGAGCA CGCATTTGAG CACTGGCAGG AGGATGCCTT CTTCGCCTCC CAGTTCCTGA ATGGTCTCAA CCCTGTCCTG ATCCGCCGCT GTCACTACCT CCCAAAGAAC TTCCCCGTCA CTGATGCCAT GGTGGCCTCA GTGTTGGGTC CTGGGACCAG CTTGCAGGCT GAGCTAGAGA AGGGCTCCCT GTTCTTGGTG GATCACGGCA TCCTCTCTGG CATCCAGACC AATGTCATTA ATGGGAAGCC TCAGTTCTCT GCGGCCCCAA TGACCCTGCT ATACCAGAGC CCAGGCTGCG GGCCGCTGCT GCCTCTCGCC ATCCAGCTCA GCCAGACCCC CGGCCCAAAC AGCCCCATCT TCCTGCCCAC TGATGACAAG TGGGACTGGT TGCTGGCCAA GACCTGGGTG CGCAATGCCG AGTTCTCCTT CCATGAGGCC CTCACGCACC TGCTGCACTC ACATCTGCTG CCTGAGGTCT TCACCCTGGC TACCCTGCGT CAGCTGCCCC ACTGCCACCC TCTCTTCAAG CTGCTGATCC CGCACACCCG ATACACCCTG CACATCAACA CACTCGCCCG GGAGCTGCTT ATCGTGCCAG GGCAGGTGGT GGACAGGTCC ACAGGCATCG GCATTGAAGG CTTCTCTGAG TTGATACAGA GGAACATGAA GCAGCTGAAC TATTCTCTCC TGTGTCTGCC TGAGGATATC CGGACCCGAG GAGTTGAAGA CATCCCAGGC TACTACTACC GTGATGATGG GATGCAGATT TGGGGTGCAG TGGAACGCTT TGTCTCTGAA ATCATCGGTA TCTACTACCC AAGTGATGAG TCTGTCCAAG ATGACAGAGA GCTCCAGGCC TGGGTCAGAG AGATCTTCTC CAAGGGCTTC CTAAACCAGG AGAGCTCAGG TATACCCTCC TCACTGGAGA CCCGGGAAGC CCTGGTGCAG TATGTCACCA TGGTGATATT CACCTGCTCA GCCAAGCATG CGGCTGTCAG TGCAGGGCAG TTTGACTCCT GTGCTTGGAT GCCCAACCTG CCACCCAGCA TGCAGCTGCC ACCACCCACC TCCAAAGGCC TGGCAACATG CGAGGGCTTC ATAGCCACCC TCCCACCTGT CAATGCCACA TGTGATGTCA TCCTTGCTCT CTGGTTGCTG AGCAAGGAGC CTGGAGACCA AAGGCCCCTG GGCACCTATC CGGATGAGCA CTTCACAGAG GAGGCCCCTC GGCGGAGCAT CGCCACCTTC CAGAGCCGCC TGGCCCAGAT CTCGAGGGGC ATCCAGGAGC GGAACCGGGG CCTGGTGCTG CCCTACACCT ACCTAGACCC TCCCCTCATC GAGAACAGCG TCTCCATCTA A. It is sometimes possible for the material contained within the vial of "ALOX15B, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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