Human Arachidonate 15-lipoxygenase B ELISA Kit | ALOX15B elisa kit

Human Arachidonate 15-lipoxygenase B ELISA Kit

Cat. Num. AAA2884741

• Gene Names: ALOX15B; 15-LOX-2
• Reactivity: Human
• Synonyms: Arachidonate 15-lipoxygenase B; Human Arachidonate 15-lipoxygenase B ELISA Kit; 15-LOX-B; 15-lipoxygenase 2; 15-LOX-2; Arachidonate 15-lipoxygenase type II; ALOX15B; 1.13.11.33; Linoleate 13-lipoxygenase 15-Lob; ALOX15B elisa kit

• Reactivity: Human
• Sequence Length: 647

• Assay Type: Sandwich
• Detection Range: 0.312-20 ng/mL
• Sensitivity: 0.098ng/mL
• Intra-Assay CV: <=4.2%
• Inter-Assay CV: <=7.6%
• Recovery: 97%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 85067499
• NCBI GeneID: 247
• NCBI Accession #: NP_001034219.1
• NCBI GenBank Nucleotide #: NM_001039130.1
• UniProt Accession #: O15296; Q8IYQ2; Q8TEV3; Q8TEV4; Q8TEV5; Q8TEV6; Q9UKM4; D3DTR2
• Molecular Weight: 72,523 Da
• NCBI Official Full Name: arachidonate 15-lipoxygenase B isoform a
• NCBI Official Synonym Full Names: arachidonate 15-lipoxygenase, type B
• NCBI Official Symbol: ALOX15B
• NCBI Official Synonym Symbols: 15-LOX-2
• NCBI Protein Information: arachidonate 15-lipoxygenase B
• UniProt Protein Name: Arachidonate 15-lipoxygenase B
• Protein Family: Arachidonate 15-lipoxygenase
• UniProt Gene Name: ALOX15B
• UniProt Synonym Gene Names: 15-LOX-B; 15-LOX-2
• UniProt Entry Name: LX15B_HUMAN

NCBI Description

This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Description

ALOX15B: Converts arachidonic acid exclusively to 15S- hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized. Belongs to the lipoxygenase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 1.13.11.33; Motility/polarity/chemotaxis; Apoptosis; Lipid Metabolism - arachidonic acid; Oxidoreductase

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: cytoplasm; cytoskeleton; cytosol; extrinsic to membrane; intracellular; membrane; nucleus; plasma membrane

Molecular Function: arachidonate 15-lipoxygenase activity; calcium ion binding; iron ion binding; lipid binding; lipoxygenase activity

Biological Process: apoptosis; arachidonic acid metabolic process; hepoxilin biosynthetic process; linoleic acid metabolic process; lipid metabolic process; lipoxygenase pathway; negative regulation of cell cycle; negative regulation of cell migration; negative regulation of cell proliferation; negative regulation of growth; positive regulation of keratinocyte differentiation; prostate gland development; regulation of epithelial cell differentiation