AARS2 cdna clone
AARS2 cDNA Clone
Gene Names
AARS2; AARSL; LKENP; COXPD8; MTALARS; MT-ALARS
Synonyms
AARS2; AARS2 cDNA Clone; AARS2 cdna clone
Sequence
ATGGCAGCGTCAGTGGCAGCTGCAGCCCGGAGGCTGCGGCGGGCCATTCGAAGGTCGCCCGCATGGCGGGGCCTCAGCCATCGGCCGCTCTCATCGGAGCCCCCTGCAGCCAAGGCCTCGGCCGTGAGGGCCGCCTTTCTGAACTTCTTTCGGGACCGCCATGGCCACCGGCTGGTGCCCTCCGCTTCCGTGCGGCCCCGCGGCGACCCCAGTTTGCTTTTTGTCAATGCGGGCATGAACCAGTTCAAGCCAATCTTTCTGGGCACCGTGGATCCACGAAGCGAGATGGCAGGCTTCCGACGTGTGGCCAACAGCCAGAAATGTGTGAGAGCTGGAGGACACCATAACGACCTGGAAGATGTGGGTCGAGACCTTTCCCATCATACCTTCTTTGAAATGCTTGGCAATTGGGCCTTTGGGGGTGAATATTTTAAGGAGGAGGCTTGTAACATGGCCTGGGAACTGCTGACTCAGGTCTATGGGATCCCTGAGGAAAGGCTCTGGATCTCCTACTTTGATGGTGACCCCAAGGCAGGGCTGGACCCAGACCTGGAGACCAGGGACATCTGGCTGAGCTTAGGGGTGCCTGCTAGCCGTGTGCTTTCCTTTGGACCACAAGAGAACTTCTGGGAGATGGGGGATACTGGCCCTTGTGGGCCCTGTACTGAGATCCACTACGACCTTGCTGGTGGGGTGGGAGCCCCCCAGCTGGTAGAGCTTTGGAACCTGGTCTTCATGCAACACAACAGAGAGGCAGATGGAAGCCTGCAGCCCCTGCCCCAGCGGCATGTGGACACAGGAATGGGCCTGGAAAGGCTGGTGGCTGTGCTGCAAGGCAAACACTCCACCTATGACACTGACCTCTTTTCCCCGCTGCTCAACGCCATACAGCAGGGCTGCAGGGCACCCCCTTACTTGGGCCGAGTAGGGGTGGCAGACGAGGGGCGCACAGACACAGCGTACCGCGTGGTGGCTGACCACATCCGCACACTCAGTGTCTGCATCTCTGATGGCGTCTTCCCTGGGATGTCAGGTCCCCCGCTGGTTCTTCGTCGGATCCTGCGTCGAGCTGTGCGTTTCTCCATGGAGATCTTAAAGGCACCACCTGGCTTCCTAGGCAGCCTGGTACCTGTAGTGGTGGAGACACTGGGAGATGCTTATCCAGAACTGCAAAGGAACTCAGCCCAGATCGCCAACCTGGTGTCAGAGGACGAGGCAGCCTTCCTGGCCTCCCTGGAGCGGGGTAGGCGGATCATTGATCGGACTCTGAGGACCCTGGGGCCTTCAGATATGTTCCCTGCTGAAGTGGCCTGGTCCTTGTCACTGTGTGGAGACCTGGGACTCCCCTTGGACATGGTAGAGCTGATGCTGGAGGAGAAAGGGGTCCAGCTAGACTCCGCTGGACTGGAGCGGTTGGCCCAAGAGGAGGCCCAGCACCGGGCACGGCAGGCTGAGCCAGTTCAGAAGCAGGGATTGTGGCTTGATGTCCATGCGCTTGGGGAGCTGCAGCGCCAAGGAGTGCCCCCAACTGACGACAGCCCCAAGTACAACTACTCCCTGCGACCCAGCGGAAGTTATGAGTTCGGCACCTGTGAGGCCCAGGTGTTGCAACTGTATACAGAGGACGGGACAGCAGTGGCCTCCGTGGGGAAAGGCCAGCGCTGTGGCCTCCTCTTGGACAGGACCAACTTCTACGCAGAACAGGGGGGCCAGGCTTCAGACCGTGGCTACCTGGTGCGGGCAGGGCAAGAGGACGTGCTGTTCCCAGTAGCCCGGGCCCAGGTCTGTGGAGGTTTCATCCTGCATGAGGCAGTAGCCCCTGAGTGCCTGCGGTTAGGGGACCAGGTGCAGCTGCATGTGGATGAGGCCTGGCGTCTAGGCTGCATGGCGAAGCATACGGCCACCCACCTGCTGAACTGGGCACTGAGGCAGACCCTGGGCCCTGGCACAGAGCAGCAGGGCTCCCATCTCAATCCTGAGCAGCTGCGCTTGGATGTGACCACCCAGACCCCATTGACCCCAGAGCAGCTCCGGGCAGTGGAGAACACTGTGCAGGAGGCCGTGGGGCAGGATGAGGCTGTGTACATGGAGGAGGTGCCCCTGGCGCTCACTGCCCAGGTCCCTGGCCTGCGCTCTCTGGATGAGGTTTACCCAGACCCTGTGCGGGTGGTATCAGTGGGGGTGCCCGTGGCCCATGCATTGGACCCAGCCTCCCAAGCCGCACTGCAGACCTCTGTGGAGCTATGCTGTGGGACGCACCTGTTACGTACTGGGGCTGTAGGGGACCTGGTTATCATCGGGGACCGCCAGCTTTCCAAGGGCACTACCCGCCTGCTGGCCGTCACTGGGGAGCAGGCCCAGCAGGCCCGAGAGCTAGGCCAGAGCCTGGCCCAGGAAGTGAAAGCGGCCACTGAGCGGCTGAGTCTGGGGAGCCGGGATGTGGCGGAGGCACTGAGGCTGTCCAAGGACATAGGACGACTCATTGAAGCTGTGGAAACTGCTGTGATGCCCCAGTGGCAGCGGCGGGAGCTGCTGGCCACAGTGAAGATGCTGCAGCGGCGTGCCAACACTGCCATCCGTAAGCTGCAAATGGGACAGGCTGCAAAAAAAACTCAGGAGCTGCTGGAGCGGCACTCGAAGGGGCCTCTGATTGTGGACACAGTCTCTGCTGAGTCTCTCTCAGTGCTGGTGAAGGTGGTACGGCAGCTGTGTGAGCAGGCCCCCAGCACGTCTGTGCTCCTACTCAGCCCCCAGCCCATGGGGAAGGTGCTGTGTGCCTGTCAGGTGGCCCAGGGTGCCATGCCCACCTTCACAGCAGAGGCCTGGGCACTGGCAGTGTGCAGCCACATGGGGGGCAAGGCGTGGGGCTCGCGAGTGGTGGCCCAAGGCACCGGAAGCACTACTGACCTGGAAGCTGCCCTCAGTATAGCCCAAACCTATGCCCTCAGCCAGCTCTGA
Sequence Length
2958
Vector
Please Inquire
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
107,340 Da
NCBI Official Full Name
Homo sapiens alanyl-tRNA synthetase 2, mitochondrial (putative), mRNA
NCBI Official Synonym Full Names
alanyl-tRNA synthetase 2, mitochondrial
NCBI Official Symbol
AARS2
NCBI Official Synonym Symbols
AARSL; LKENP; COXPD8; MTALARS; MT-ALARS
NCBI Protein Information
alanine--tRNA ligase, mitochondrial
UniProt Protein Name
Alanine--tRNA ligase, mitochondrial
UniProt Gene Name
AARS2
UniProt Synonym Gene Names
AlaRS
UniProt Entry Name
SYAM_HUMAN
NCBI Description
The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011]
Uniprot Description
AARSL: Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Defects in AARS2 are the cause of combined oxidative phosphorylation deficiency type 8 (COXPD8). A mitochondrial disease characterized by a lethal infantile hypertrophic cardiomyopathy, generalized muscle dysfunction and some neurologic involvement. The liver is not affected. Belongs to the class-II aminoacyl-tRNA synthetase family.
Protein type: Translation; EC 6.1.1.7; Ligase
Chromosomal Location of Human Ortholog: 6p21.1
Cellular Component: cytosol; mitochondrion
Molecular Function: alanine-tRNA ligase activity; amino acid binding; tRNA binding
Biological Process: mitochondrial respiratory chain complex assembly; tRNA modification
Disease: Combined Oxidative Phosphorylation Deficiency 8; Leukoencephalopathy, Progressive, With Ovarian Failure
Research Articles on AARS2
Similar Products
Product Notes
The AARS2 aars2 (Catalog #AAA1270089) is a cDNA Clone and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: ATGGCAGCGT CAGTGGCAGC TGCAGCCCGG AGGCTGCGGC GGGCCATTCG AAGGTCGCCC GCATGGCGGG GCCTCAGCCA TCGGCCGCTC TCATCGGAGC CCCCTGCAGC CAAGGCCTCG GCCGTGAGGG CCGCCTTTCT GAACTTCTTT CGGGACCGCC ATGGCCACCG GCTGGTGCCC TCCGCTTCCG TGCGGCCCCG CGGCGACCCC AGTTTGCTTT TTGTCAATGC GGGCATGAAC CAGTTCAAGC CAATCTTTCT GGGCACCGTG GATCCACGAA GCGAGATGGC AGGCTTCCGA CGTGTGGCCA ACAGCCAGAA ATGTGTGAGA GCTGGAGGAC ACCATAACGA CCTGGAAGAT GTGGGTCGAG ACCTTTCCCA TCATACCTTC TTTGAAATGC TTGGCAATTG GGCCTTTGGG GGTGAATATT TTAAGGAGGA GGCTTGTAAC ATGGCCTGGG AACTGCTGAC TCAGGTCTAT GGGATCCCTG AGGAAAGGCT CTGGATCTCC TACTTTGATG GTGACCCCAA GGCAGGGCTG GACCCAGACC TGGAGACCAG GGACATCTGG CTGAGCTTAG GGGTGCCTGC TAGCCGTGTG CTTTCCTTTG GACCACAAGA GAACTTCTGG GAGATGGGGG ATACTGGCCC TTGTGGGCCC TGTACTGAGA TCCACTACGA CCTTGCTGGT GGGGTGGGAG CCCCCCAGCT GGTAGAGCTT TGGAACCTGG TCTTCATGCA ACACAACAGA GAGGCAGATG GAAGCCTGCA GCCCCTGCCC CAGCGGCATG TGGACACAGG AATGGGCCTG GAAAGGCTGG TGGCTGTGCT GCAAGGCAAA CACTCCACCT ATGACACTGA CCTCTTTTCC CCGCTGCTCA ACGCCATACA GCAGGGCTGC AGGGCACCCC CTTACTTGGG CCGAGTAGGG GTGGCAGACG AGGGGCGCAC AGACACAGCG TACCGCGTGG TGGCTGACCA CATCCGCACA CTCAGTGTCT GCATCTCTGA TGGCGTCTTC CCTGGGATGT CAGGTCCCCC GCTGGTTCTT CGTCGGATCC TGCGTCGAGC TGTGCGTTTC TCCATGGAGA TCTTAAAGGC ACCACCTGGC TTCCTAGGCA GCCTGGTACC TGTAGTGGTG GAGACACTGG GAGATGCTTA TCCAGAACTG CAAAGGAACT CAGCCCAGAT CGCCAACCTG GTGTCAGAGG ACGAGGCAGC CTTCCTGGCC TCCCTGGAGC GGGGTAGGCG GATCATTGAT CGGACTCTGA GGACCCTGGG GCCTTCAGAT ATGTTCCCTG CTGAAGTGGC CTGGTCCTTG TCACTGTGTG GAGACCTGGG ACTCCCCTTG GACATGGTAG AGCTGATGCT GGAGGAGAAA GGGGTCCAGC TAGACTCCGC TGGACTGGAG CGGTTGGCCC AAGAGGAGGC CCAGCACCGG GCACGGCAGG CTGAGCCAGT TCAGAAGCAG GGATTGTGGC TTGATGTCCA TGCGCTTGGG GAGCTGCAGC GCCAAGGAGT GCCCCCAACT GACGACAGCC CCAAGTACAA CTACTCCCTG CGACCCAGCG GAAGTTATGA GTTCGGCACC TGTGAGGCCC AGGTGTTGCA ACTGTATACA GAGGACGGGA CAGCAGTGGC CTCCGTGGGG AAAGGCCAGC GCTGTGGCCT CCTCTTGGAC AGGACCAACT TCTACGCAGA ACAGGGGGGC CAGGCTTCAG ACCGTGGCTA CCTGGTGCGG GCAGGGCAAG AGGACGTGCT GTTCCCAGTA GCCCGGGCCC AGGTCTGTGG AGGTTTCATC CTGCATGAGG CAGTAGCCCC TGAGTGCCTG CGGTTAGGGG ACCAGGTGCA GCTGCATGTG GATGAGGCCT GGCGTCTAGG CTGCATGGCG AAGCATACGG CCACCCACCT GCTGAACTGG GCACTGAGGC AGACCCTGGG CCCTGGCACA GAGCAGCAGG GCTCCCATCT CAATCCTGAG CAGCTGCGCT TGGATGTGAC CACCCAGACC CCATTGACCC CAGAGCAGCT CCGGGCAGTG GAGAACACTG TGCAGGAGGC CGTGGGGCAG GATGAGGCTG TGTACATGGA GGAGGTGCCC CTGGCGCTCA CTGCCCAGGT CCCTGGCCTG CGCTCTCTGG ATGAGGTTTA CCCAGACCCT GTGCGGGTGG TATCAGTGGG GGTGCCCGTG GCCCATGCAT TGGACCCAGC CTCCCAAGCC GCACTGCAGA CCTCTGTGGA GCTATGCTGT GGGACGCACC TGTTACGTAC TGGGGCTGTA GGGGACCTGG TTATCATCGG GGACCGCCAG CTTTCCAAGG GCACTACCCG CCTGCTGGCC GTCACTGGGG AGCAGGCCCA GCAGGCCCGA GAGCTAGGCC AGAGCCTGGC CCAGGAAGTG AAAGCGGCCA CTGAGCGGCT GAGTCTGGGG AGCCGGGATG TGGCGGAGGC ACTGAGGCTG TCCAAGGACA TAGGACGACT CATTGAAGCT GTGGAAACTG CTGTGATGCC CCAGTGGCAG CGGCGGGAGC TGCTGGCCAC AGTGAAGATG CTGCAGCGGC GTGCCAACAC TGCCATCCGT AAGCTGCAAA TGGGACAGGC TGCAAAAAAA ACTCAGGAGC TGCTGGAGCG GCACTCGAAG GGGCCTCTGA TTGTGGACAC AGTCTCTGCT GAGTCTCTCT CAGTGCTGGT GAAGGTGGTA CGGCAGCTGT GTGAGCAGGC CCCCAGCACG TCTGTGCTCC TACTCAGCCC CCAGCCCATG GGGAAGGTGC TGTGTGCCTG TCAGGTGGCC CAGGGTGCCA TGCCCACCTT CACAGCAGAG GCCTGGGCAC TGGCAGTGTG CAGCCACATG GGGGGCAAGG CGTGGGGCTC GCGAGTGGTG GCCCAAGGCA CCGGAAGCAC TACTGACCTG GAAGCTGCCC TCAGTATAGC CCAAACCTAT GCCCTCAGCC AGCTCTGA. It is sometimes possible for the material contained within the vial of "AARS2, cDNA Clone" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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