SDS-Page
(Recombinant Human K-Cadherin Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 95-100 kDa.)
K-Cadherin Recombinant Protein | CDH6 recombinant protein
Recombinant Human K-Cadherin Protein
Gene Names
CDH6; CAD6; KCAD
Purity
>95% by SDS-PAGE.
Synonyms
K-Cadherin; Recombinant Human K-Cadherin Protein; CDH6 recombinant protein
Host
HEK293 Cells
Purity/Purification
>95% by SDS-PAGE.
Form/Format
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Sequence
TLSTPLSKRTSGFPAKKRALELSGNSKNELNRSKRSWMWNQFFLLEEYTGSDYQYVGKLHSDQDRGDGSLKYILSGDGAGDLFIINENTGDIQATKRLDREEKPVYILRAQAINRRTGRPVEPESEFIIKIHDINDNEPIFTKEVYTATVPEMSDVGTFVVQVTATDADDPTYGNSAKVVYSILQGQPYFSVESETGIIKTALLNMDRENREQYQVVIQAKDMGGQMGGLSGTTTVNITLTDVNDNPPRFPQSTYQFKTPESSPPGTPIGRIKASDADVGENAEIEYSITDGEGLDMFDVITDQETQEGIITVKKLLDFEKKKVYTLKVEASNPYVEPRFLYLGPFKDSATVRIVVEDVDEPPVFSKLAYILQIREDAQINTTIGSVTAQDPDAARNPVKYSVDRHTDMDRIFNIDSGNGSIFTSKLLDRETLLWHNITVIATEINNPKQSSRVPLYIKVLDVNDNAPEFAEFYETFVCEKAKADQLIQTLHAVDKDDPYSGHQFSFSLAPEAASGSNFTIQDNKDNTAGILTRKNGYNRHEMSTYLLPVVISDNDYPVQSSTGTVTVRVCACDHHGNMQSCHAEALIHPTGLSTGA
Sequence Length
790
Species
Human
Endotoxin
< 0.1 EU/ug of the protein by LAL method.
Reconstitution
Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water.
Tag
6xHis tag at the C-terminus
Preparation and Storage
Store the lyophilized protein at -20 degree C to -80 degree C for long term.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
SDS-Page
(Recombinant Human K-Cadherin Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 95-100 kDa.)
SDS-Page
(Recombinant Human K-Cadherin Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 95-100 kDa.)
Related Product Information for CDH6 recombinant protein
Description: Recombinant Human K-Cadherin Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr 19 - Ala 615) of human K-Cadherin (Accession #NP_004923.1) fused with a 6xHis tag at the C-terminus.
Background: CDH6 is a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus, Cadherin-6 is a new prognostic factor for renal cancer.
Background: CDH6 is a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type-II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus, Cadherin-6 is a new prognostic factor for renal cancer.
Product Categories/Family for CDH6 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
cadherin-6 isoform 1 preproprotein
NCBI Official Synonym Full Names
cadherin 6
NCBI Official Symbol
CDH6
NCBI Official Synonym Symbols
CAD6; KCAD
NCBI Protein Information
cadherin-6
UniProt Protein Name
Cadherin-6
Protein Family
UniProt Gene Name
CDH6
UniProt Synonym Gene Names
K-cadherin
UniProt Entry Name
CADH6_HUMAN
NCBI Description
This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
Research Articles on CDH6
Similar Products
Product Notes
The CDH6 cdh6 (Catalog #AAA9141795) is a Recombinant Protein produced from HEK293 Cells and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below: TLSTPLSKRT SGFPAKKRAL ELSGNSKNEL NRSKRSWMWN QFFLLEEYTG SDYQYVGKLH SDQDRGDGSL KYILSGDGAG DLFIINENTG DIQATKRLDR EEKPVYILRA QAINRRTGRP VEPESEFIIK IHDINDNEPI FTKEVYTATV PEMSDVGTFV VQVTATDADD PTYGNSAKVV YSILQGQPYF SVESETGIIK TALLNMDREN REQYQVVIQA KDMGGQMGGL SGTTTVNITL TDVNDNPPRF PQSTYQFKTP ESSPPGTPIG RIKASDADVG ENAEIEYSIT DGEGLDMFDV ITDQETQEGI ITVKKLLDFE KKKVYTLKVE ASNPYVEPRF LYLGPFKDSA TVRIVVEDVD EPPVFSKLAY ILQIREDAQI NTTIGSVTAQ DPDAARNPVK YSVDRHTDMD RIFNIDSGNG SIFTSKLLDR ETLLWHNITV IATEINNPKQ SSRVPLYIKV LDVNDNAPEF AEFYETFVCE KAKADQLIQT LHAVDKDDPY SGHQFSFSLA PEAASGSNFT IQDNKDNTAG ILTRKNGYNR HEMSTYLLPV VISDNDYPVQ SSTGTVTVRV CACDHHGNMQ SCHAEALIHP TGLSTGA. It is sometimes possible for the material contained within the vial of "K-Cadherin, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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