Cadherin-6 / CDH6 Recombinant Protein | CDH6 recombinant protein

Recombinant Human Cadherin-6 / CDH6 Protein (His tag)

Cat. Num. AAA2546482

• Gene Names: CDH6; CAD6; KCAD
• Purity: > 85 % as determined by SDS-PAGE
• Synonyms: Cadherin-6 / CDH6; Recombinant Human Cadherin-6 / CDH6 Protein (His tag); KCAD; CDH6; CDH6 recombinant protein

• Host: Human Cells
• Purity/Purification: > 85 % as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 663

• Application Notes: The pro form of recombinant human CDH6 consists of 609 amino acids and predictes a molecular mass of 68 kDa. In SDS-PAGE under reducing conditions, it migrates with the apparent molecular mass of 90-100 kDa due to glycosylation.
• Predicted N Terminal: Thr 19 & Ser 54
• Endotoxin: < 1.0 EU per mug of the protein as determined by the LAL method
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CDH6 recombinant protein

Background: Cadherins are a family of calcium-dependent, cell-cell adhesion molecules that play an important morphoregulatory role in a wide variety of tissues. Alterations in cadherin function have been implicated in tumor progression in a number of adenocarcinomas. Cadherin-6 (CDH6), also known as K-cadherin (KCAD), is a type -II classic cadherin cell-cell adhesion molecules, which are expressed in graded or areal patterns, as well as layer-specific patterns, in the cortical plate. Human Cadherin-6 is synthesized as a 790 aa type I transmembrane glycoprotein that contains a 18 aa signal peptide, a 35 aa propeptide, a 562 aa extracellular region, a 21 aa transmembrane segment, and a 154 aa cytoplasmic domain. There are five cadherin domains of approximately 110 aa each in the extracellular region. Cadherin-6 is highly expressed in brain, cerebellum, and kidney, and may contribute to the formation of the segmental structure of the early brain, as well as the development of renal proximal tubules. Weak expression is also detected lung, pancreas, and gastric mucosa. Additionally, it is specifically expressed in the proximal tubule of normal kidneys and in renal cell cancer. Thus, Cadherin-6 is a new prognostic factor for renal cancer.

Description: A DNA sequence encoding the extracellular domain of human CDH6 (AAH00019.1) precursor (Met 1-Ala 615) was fused with a polyhistidine tag at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 12652559
• NCBI GeneID: 1004
• Molecular Weight: 73,864 Da
• NCBI Official Full Name: CDH6 protein
• NCBI Official Synonym Full Names: cadherin 6
• NCBI Official Symbol: CDH6
• NCBI Official Synonym Symbols: CAD6; KCAD
• NCBI Protein Information: cadherin-6
• UniProt Protein Name: Cadherin-6
• Protein Family: Cadherin
• UniProt Gene Name: CDH6
• UniProt Synonym Gene Names: K-cadherin

NCBI Description

This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]

Uniprot Description

CDH6: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5p13.3

Cellular Component: plasma membrane

Biological Process: cell adhesion