CD8B recombinant protein

Human CellExp CD8b, Human Recombinant

Cat. Num. AAA849871

• Gene Names: CD8B; LY3; P37; LEU2; LYT3; CD8B1
• Purity: >=95% by SDS-PAGE
• Synonyms: CD8b; Human CellExp CD8b; Human Recombinant; T cell surface glycoprotein CD8 beta chain; T lymphocyte surface glycoprotein beta chain; CD8b antigen; CD8 antigen beta polypeptide 1 (p37); CD8 beta; CD8B_HUMAN; CD8B1; Leu2; Ly3; LYT3; MGC119115; P37; CD8B recombinant protein

• Host: HEK293 cells
• Purity/Purification: >=95% by SDS-PAGE
• Form/Format: Lyophilized from 0.22 um filtered solution in PBS pH7.4

• Gene Source: Human
• Reconstitution Instruction: Reconstitute in distilled water.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Testing Data

Related Product Information for CD8B recombinant protein

The T-cell surface glycoprotein CD8 beta chain, also called CD8 beta (CD8b), P37 or LEU2 is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. It plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. Being a member of functional coreceptors, CD8 functions either as a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. In T-cells, CD8b functions primarily as a coreceptor for class I MHC molecules. It initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). Additionally, CD8b plays a critical role in thymic selection of CD8+ T-cells. CD8b is thought to play a role in the process of T-cell mediated killing.

Product Categories/Family for CD8B recombinant protein

Proteins; Enzymes; Human cell expressed recombinant proteins; Cytokines; Growth Factors & Hormones; CDs; Cytokines; Cytokines & Growth Factors (A-Z); Proteins & Enzymes (A-Z)

NCBI and Uniprot Product Information

• NCBI GI #: 116032
• NCBI GeneID: 926
• UniProt Accession #: P10966; P14860; P14861; Q15980; Q496E0; Q496E1; Q496E2; Q9UDB4; Q9UDB5; Q9UDB6; Q9UDB7; Q9UDB8
• Molecular Weight: 210
• NCBI Official Full Name: T-cell surface glycoprotein CD8 beta chain
• NCBI Official Synonym Full Names: CD8b molecule
• NCBI Official Symbol: CD8B
• NCBI Official Synonym Symbols: LY3; P37; LEU2; LYT3; CD8B1
• NCBI Protein Information: T-cell surface glycoprotein CD8 beta chain; CD8 antigen, beta polypeptide 1 (p37); T lymphocyte surface glycoprotein beta chain
• UniProt Protein Name: T-cell surface glycoprotein CD8 beta chain
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD8B
• UniProt Synonym Gene Names: CD8B1
• UniProt Entry Name: CD8B_HUMAN

NCBI Description

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

Uniprot Description

CD8B: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p12

Cellular Component: T cell receptor complex; integral to plasma membrane; early endosome membrane; plasma membrane; extracellular region; external side of plasma membrane

Molecular Function: protein binding; MHC class I protein binding; coreceptor activity

Biological Process: regulation of immune response; T cell activation; viral reproduction; immune response; regulation of defense response to virus by virus; transmembrane receptor protein tyrosine kinase signaling pathway