CD6 / Cluster of Differentiation 6 Recombinant Protein | CD6 recombinant protein

Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag)

Cat. Num. AAA2545130

• Gene Names: CD6; TP120
• Purity: > 95 % as determined by SDS-PAGE.
• Synonyms: CD6 / Cluster of Differentiation 6; Human CD6 / Cluster of Differentiation 6 Protein (Fc Tag); CD6; CD6 recombinant protein

• Host: Human Cells
• Purity/Purification: > 95 % as determined by SDS-PAGE.
• Form/Format: Lyophilized from sterile PBS, pH 7.4
• Sequence Length: 668

• Application Notes: The recombinant human CD6 consists of 619 amino acids and predicts a molecular mass of 67.3 kDa.
• Predicted N Terminal: His 18
• Endotoxin: < 1.0 EU per mug protein as determined by the LAL method.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -70 degree C

SDS-PAGE

Related Product Information for CD6 recombinant protein

Background: T-cell differentiation antigen CD6, also known as TP120 and CD6, is a single-pass type I membrane protein which contains three SRCR domains. CD6 / TP120 is a cell surface glycoprotein expressed primarily on T cells, it may function as a costimulatory molecule and may play a role in autoreactive immune responses. CD6 / TP120 is expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain. CD6 ligand termed CD166 (previously known as activated leukocyte cell adhesion molecule, ALCAM) has been identified and shown to be expressed on activated T cells, B cells, thymic epithelium, keratinocytes, and in rheumatoid arthritis synovial tissue. CD6 / TP120 binds to activated leukocyte cell adhesion molecule (CD166), and is considered as a costimulatory molecule involved in lymphocyte activation and thymocyte development. CD6 / TP120 partially associates with the TCR / CD3 complex and colocalizes with it at the center of the mature immunological synapse (IS) on T lymphocytes. During thymic development CD6-dependent signals may contribute both to thymocyte survival, and to the overall functional avidity of selection in both man and mouse.

Description: A DNA sequence encoding the human CD6 (NP_006716.3) (Met1-Glu398) was expressed with the Fc region of human IgG1 at the C-terminus.

NCBI and Uniprot Product Information

• NCBI GI #: 194018748
• NCBI GeneID: 923
• NCBI Accession #: NP_006716.3
• NCBI GenBank Nucleotide #: NM_006725.4
• UniProt Accession #: P30203; Q9UMF2; Q9Y4K7; Q9Y4K8; Q9Y4K9; Q9Y4L0; A4KAD4; A4KAD5
• Molecular Weight: 60,572 Da
• NCBI Official Full Name: T-cell differentiation antigen CD6 isoform 1
• NCBI Official Synonym Full Names: CD6 molecule
• NCBI Official Symbol: CD6
• NCBI Official Synonym Symbols: TP120
• NCBI Protein Information: T-cell differentiation antigen CD6
• UniProt Protein Name: T-cell differentiation antigen CD6
• Protein Family: T-cell differentiation antigen
• UniProt Gene Name: CD6

NCBI Description

This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

CD6: a type I membrane protein involved in cell adhesion. Binds to CD166. Expressed on thymocytes, peripheral T cells, a subset of B cells, and a subset of neurons. Mediates the binding of developing thymocytes with thymic epithelial cells. CD6- T cells are less autoreactive than CD6+ T cells. Phosphorylated on tyrosines and serines following T cell antigen receptor signaling. Five splice-variant isoforms have been described.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q12.2

Cellular Component: immunological synapse; integral to plasma membrane; intrinsic to plasma membrane; T cell receptor complex

Molecular Function: lipopolysaccharide binding; protein binding

Biological Process: acute inflammatory response to antigenic stimulus; formation of immunological synapse; heterophilic cell adhesion; lipopolysaccharide-mediated signaling pathway; positive regulation of T cell proliferation; response to lipopolysaccharide