CD58 recombinant protein

CD58 Protein, Human, Recombinant (His Tag)

Cat. Num. AAA8121161

• Gene Names: CD58; ag3; LFA3; LFA-3
• Purity: >95% as determined by SDS-PAGE
• Synonyms: CD58; CD58 Protein; Human; Recombinant (His Tag); Human LFA-3/CD58 Protein (His Tag); ag3 Protein; LFA-3 Protein; LFA3 Protein; CD58 molecule; CD58 recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >95% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Met1-Arg215

• Species: Human
• Endotoxin: <1.0EU per ug of the protein as determined by the LAL method
• Predicted N Terminal: Phe 29
• Tag: C-His
• Protein Construction: A DNA sequence encoding the human CD58 (AAH05930.1)(Met1-Arg215) was expressed with a polyhistidine tag at the C-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Related Product Information for CD58 recombinant protein

Background: CD53 is a member of the transmembrane 4 superfamily, also called the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. These proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. CD53 is a cell surface glycoprotein that is known to complex with integrins. Familial deficiency of CD53 gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. CD53 contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation.

References

Rochelle JM. et al., 1993, Int Immunol. 5 (2): 209-16. Virtaneva KI. et al., 1993, Immunogenetics. 37 (6): 461-5. Horejsa- V. et al., 1991, FEBS Lett. 288 (1-2): 1-4.

NCBI and Uniprot Product Information

• NCBI GI #: 13543545
• NCBI GeneID: 965
• Molecular Weight: 27,960 Da
• NCBI Official Full Name: CD58 protein
• NCBI Official Synonym Full Names: CD58 molecule
• NCBI Official Symbol: CD58
• NCBI Official Synonym Symbols: ag3; LFA3; LFA-3
• NCBI Protein Information: lymphocyte function-associated antigen 3
• Protein Family: Lymphocyte function-associated antigen

NCBI Description

This gene encodes a member of the immunoglobulin superfamily. The encoded protein is a ligand of the T lymphocyte CD2 protein, and functions in adhesion and activation of T lymphocytes. The protein is localized to the plasma membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2009]