CD53 recombinant protein

Recombinant Human CD53 protein, C-His Tag

Cat. Num. AAA1560016

• Gene Names: CD53; MOX44; TSPAN25
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD53; Recombinant Human CD53 protein; C-His Tag; MOX44; TSPAN25; CD53 recombinant protein

• Host: Mammalian cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Human
• Endotoxin level: <1.0EU per ug of the protein as determined by the LAL method
• Reconstitution: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details
• Construction: A DNA sequence encoding the human CD53 (Glu107-Asn181) was fused with the C-terminal His Tag
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; Shipping: In general, proteins are provided as lyophilized powder/frozen liquid.

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Product Categories/Family for CD53 recombinant protein

CD protein

NCBI and Uniprot Product Information

• NCBI GI #: 10834972
• NCBI GeneID: 963
• NCBI Accession #: NP_000551.1
• NCBI GenBank Nucleotide #: NM_000560.3
• UniProt Accession #: P19397; Q5U0D6; B2R905
• Molecular Weight: 24,341 Da
• NCBI Official Full Name: leukocyte surface antigen CD53
• NCBI Official Synonym Full Names: CD53 molecule
• NCBI Official Symbol: CD53
• NCBI Official Synonym Symbols: MOX44; TSPAN25
• NCBI Protein Information: leukocyte surface antigen CD53; CD53 antigen; CD53 glycoprotein; CD53 tetraspan antigen; antigen MOX44 identified by monoclonal antibody MRC-OX44; cell surface antigen; cell surface glycoprotein CD53; tetraspanin-25; transmembrane glycoprotein; tspan-25
• UniProt Protein Name: Leukocyte surface antigen CD53
• Protein Family: Leukocyte surface antigen
• UniProt Gene Name: CD53
• UniProt Synonym Gene Names: MOX44; TSPAN25; Tspan-25
• UniProt Entry Name: CD53_HUMAN

NCBI Description

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. It contributes to the transduction of CD2-generated signals in T cells and natural killer cells and has been suggested to play a role in growth regulation. Familial deficiency of this gene has been linked to an immunodeficiency associated with recurrent infectious diseases caused by bacteria, fungi and viruses. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]

Uniprot Description

CD53: May be involved in growth regulation in hematopoietic cells. Belongs to the tetraspanin (TM4SF) family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p13

Cellular Component: cell surface; plasma membrane; integral to membrane; immunological synapse; intercellular junction

Molecular Function: protein binding

Biological Process: signal transduction