CD1E recombinant protein

Recombinant Human CD1E protein

Cat. Num. AAA1561443

• Gene Names: CD1E; R2; CD1A
• Purity: >90% as determined by SDS-PAGE
• Synonyms: CD1E; Recombinant Human CD1E protein; T-cell surface glycoprotein CD1e; membrane-associated; hCD1e; R2G1; CD1e; CD1E recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized. Lyophilized from PBS pH 7.4, 0.2% NLS, 5% Trehalose, 5% Mannose, 1mM EDTA.

• Species: Homo sapiens (Human)
• Protein Construction: A DNA sequence encoding the human CD1E (Met39-Ala276) was fused with His tag
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Preparation and Storage: Store at 2 to 8 degree C for one week. Store at -20 to -80 degree C for twelve months from the date of receipt. Use a manual defrost freezer and avoid repeated freeze thaw cycles.; In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Related Product Information for CD1E recombinant protein

T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active.

Product Categories/Family for CD1E recombinant protein

Protein

NCBI and Uniprot Product Information

• NCBI GI #: 110618230
• NCBI GeneID: 913
• NCBI Accession #: NP_001036048.1
• NCBI GenBank Nucleotide #: NM_001042583.2
• UniProt Accession #: P15812; Q5TDJ9; Q5TDK3; Q5TDK4; Q5TDK5; Q5TDK6; Q5TDK8; Q5TDL1; Q712E4; Q712E5; Q712E6; B4DZV3
• Molecular Weight: 43,626 Da
• NCBI Official Full Name: T-cell surface glycoprotein CD1e, membrane-associated isoform b
• NCBI Official Synonym Full Names: CD1e molecule
• NCBI Official Symbol: CD1E
• NCBI Official Synonym Symbols: R2; CD1A
• NCBI Protein Information: T-cell surface glycoprotein CD1e, membrane-associated; R2G1; hCD1e; thymocyte antigen CD1E; CD1E antigen, e polypeptide; leukocyte differentiation antigen; differentiation antigen CD1-alpha-3
• UniProt Protein Name: T-cell surface glycoprotein CD1e, membrane-associated
• Protein Family: T-cell surface glycoprotein
• UniProt Gene Name: CD1E
• UniProt Synonym Gene Names: hCD1e; sCD1e
• UniProt Entry Name: CD1E_HUMAN

NCBI Description

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes within Golgi compartments, endosomes, and lysosomes, and is cleaved into a stable soluble form. The soluble form is required for the intracellular processing of some glycolipids into a form that can be presented by other CD1 family members. Many alternatively spliced transcript variants encoding different isoforms have been described. Additional transcript variants have been found; however, their biological validity has not been determined. [provided by RefSeq, Jun 2010]

Uniprot Description

CD1E: T-cell surface glycoprotein CD1e, soluble is required for the presentation of glycolipid antigens on the cell surface. The membrane-associated form is not active. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q23.1

Cellular Component: Golgi membrane; lysosomal lumen; integral to plasma membrane; late endosome; early endosome; plasma membrane

Molecular Function: beta-2-microglobulin binding; exogenous lipid antigen binding; endogenous lipid antigen binding

Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; immune response