Macrophage Inflammatory protein-3 Recombinant Protein | MIP 3 recombinant protein

Recombinant Human Macrophage Inflammatory protein-3 (CCL23), T7 Tag

Cat. Num. AAA144013

• Gene Names: CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19
• Purity: Greater than 95.0% as determined by SDS-PAGE.
• Synonyms: Macrophage Inflammatory protein-3; Recombinant Human Macrophage Inflammatory protein-3 (CCL23); T7 Tag; MIP 3 Human; Macrophage Inflammatory protein-3 (CCL23) Human Recombinant; Small inducible cytokine A19; CCL19; Macrophage inflammatory protein 3 beta; MIP-3- beta; EBI1-ligand chemokine; ELC; Beta chemokine exodus-3; CK beta-11; chemokine (C-C motif) ligand 19; CKb11; MIP3B; MIP-3b; SCYA19; MGC34433; MIP 3; T7; MIP 3 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 95.0% as determined by SDS-PAGE.
• Form/Format: MIP3B Human solution containing 1x PBS pH-7.4 and 10% glycerol.; Sterile filtered colorless solution.
• Sequence: MASMTGGQQM GRGSHMGTND AEDCCLSVTQ KPIPGYIVRN FHYLLIKDGC RVPAVVFTTL RGRQLCAPPD QPWVERIIQR LQRTSAKMKR RSS
• Sequence Length: 98

• Preparation and Storage: CCL19 Human although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. Please prevent freeze thaw cycles.

Related Product Information for MIP 3 recombinant protein

Description: CCL19 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 93 amino acids (22098 a.a.) and having a molecular mass of 10.4 kDa. The CCL19 is fused to a 16 amino acid T7 tag at N-Terminus and purified by proprietary chromatographic techniques.

Introduction: Chemokine (C-C motif) ligand 19 (CCL19) is a small cytokine belonging to the CC chemokine family that is also known as EBI1 ligand chemokine (ELC) and macrophage inflammatory protein-3-beta (MIP-3-beta). CCL19 is expressed abundantly in thymus and lymph nodes, with moderate levels in trachea and colon and low levels in stomach, small intestine, lung, kidney and spleen. The gene for CCL19 is located on human chromosome 9. This chemokine elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells.

Product Categories/Family for MIP 3 recombinant protein

Chemokines; MIP

NCBI and Uniprot Product Information

• NCBI GI #: 5454040
• NCBI GeneID: 6363
• NCBI Accession #: NP_006265.1
• NCBI GenBank Nucleotide #: NM_006274.2
• UniProt Accession #: Q99731; O00697; O00736
• Molecular Weight: 10,993 Da
• NCBI Official Full Name: C-C motif chemokine 19
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 19
• NCBI Official Symbol: CCL19
• NCBI Official Synonym Symbols: ELC; CKb11; MIP3B; MIP-3b; SCYA19
• NCBI Protein Information: C-C motif chemokine 19; CC chemokine ligand 19; CK beta-11; EBI1 ligand chemokine; EBI1-ligand chemokine; MIP-3-beta; beta chemokine exodus-3; beta-chemokine exodus-3; epstein-Barr virus-induced molecule 1 ligand chemokine; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; small inducible cytokine subfamily A (Cys-Cys), member 19; small-inducible cytokine A19
• UniProt Protein Name: C-C motif chemokine 19
• UniProt Gene Name: CCL19
• UniProt Synonym Gene Names: ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta
• UniProt Entry Name: CCL19_HUMAN

NCBI Description

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Sep 2014]

Uniprot Description

CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Secreted, signal peptide; Motility/polarity/chemotaxis; Secreted

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR chemokine receptor binding; chemokine activity; chemokine receptor binding; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of endocytosis; positive regulation of NF-kappaB import into nucleus; positive regulation of interleukin-1 beta secretion; activation of JNK activity; positive regulation of receptor-mediated endocytosis; dendritic cell chemotaxis; positive regulation of T cell proliferation; cell communication; establishment of T cell polarity; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation