Macrophage Inflammatory Protein 3 beta, aa22-98 Recombinant Protein | CCL19 recombinant protein

Macrophage Inflammatory Protein 3 beta, aa22-98, Recombinant, Human (MIP-3-beta, MIP3B, MIP-3b, Beta Chemokine Exodus-3, C-C Motif Chemokine 19, Chemokine (C-C Motif) Ligand 19, CCL19, CK beta-11, CKb11, Epstein-Barr Virus-induced Molecule 1 Ligand Chemok

Cat. Num. AAA637317

• Gene Names: CCL19; ELC; CKb11; MIP3B; MIP-3b; SCYA19
• Purity: Purified; ~95% (SDS-PAGE).
• Synonyms: Macrophage Inflammatory Protein 3 beta; aa22-98; Recombinant; Human (MIP-3-beta; MIP3B; MIP-3b; Beta Chemokine Exodus-3; C-C Motif Chemokine 19; Chemokine (C-C Motif) Ligand 19; CCL19; CK beta-11; CKb11; Epstein-Barr Virus-induced Molecule 1 Ligand Chemok; Non-Neuronal Enolase (NNE); Enolase-1; ENO1; MBP-1; MYC promoter-binding protein 1; PPH; tau-crystallin; 2 phospho D glycerate hydro lyase; alpha enolase; C myc promoter binding protein; EC4.2.1.11; ENO1L1; Enolase 1; Enolase 1 (alpha); Enolase 1 (alpha) like 1; MBP1; MBP; MYC promoter binding protein 1; NNE; Non neural enolase; Phosphopyruvate hydratase; Plasminogen binding protein.; CCL19 recombinant protein

• Host: E Coli
• Purity/Purification: Purified; ~95% (SDS-PAGE).
• Form/Format: Supplied as a liquid in PBS pH 7.4, 10% glycerol.

• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing.. Store at -20 degree C. Aliquots are stable for at least 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

SDS-Page

(15% SDS-PAGE (3ug))

Related Product Information for CCL19 recombinant protein

CCL19 is a small cytokine belonging to the CC chemokine family that is also known as thymus and activation regulated chemokine (TARC). This protein is involved in immunoregulatory and inflammatory processes. It elicits its effects on its target cells by binding to the chemokine receptor chemokine receptor CCR7. It attracts certain cells of the immune system, including dendritic cells and antigen-engaged B cells, CCR7+ effector-memory T-Cells. Recombinant human CCL19 protein, fused to T7-tag at N-terminus, expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

Product Categories/Family for CCL19 recombinant protein

Growth Factors; Cytokines; Growth Factors-MIP

NCBI and Uniprot Product Information

• NCBI GI #: 1791003
• NCBI GeneID: 6363
• UniProt Accession #: Q99731; O00697; O00736
• Molecular Weight: 47.1 kDa (434aa), confirmed by MALDI-TOF
• NCBI Official Full Name: macrophage inflammatory protein 3 beta
• NCBI Official Synonym Full Names: chemokine (C-C motif) ligand 19
• NCBI Official Symbol: CCL19
• NCBI Official Synonym Symbols: ELC; CKb11; MIP3B; MIP-3b; SCYA19
• NCBI Protein Information: C-C motif chemokine 19; exodus-3; CK beta-11; MIP-3-beta; EBI1 ligand chemokine; EBI1-ligand chemokine; CC chemokine ligand 19; beta chemokine exodus-3; beta-chemokine exodus-3; small-inducible cytokine A19; macrophage inflammatory protein 3 beta; macrophage inflammatory protein 3-beta; epstein-Barr virus-induced molecule 1 ligand chemokine; small inducible cytokine subfamily A (Cys-Cys), member 19
• UniProt Protein Name: C-C motif chemokine 19
• Protein Family: C-C motif chemokine
• UniProt Gene Name: CCL19
• UniProt Synonym Gene Names: ELC; MIP3B; SCYA19; EBI1 ligand chemokine; ELC; MIP-3-beta
• UniProt Entry Name: CCL19_HUMAN

NCBI Description

This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene may play a role in normal lymphocyte recirculation and homing. It also plays an important role in trafficking of T cells in thymus, and in T cell and B cell migration to secondary lymphoid organs. It specifically binds to chemokine receptor CCR7. [provided by RefSeq, Jul 2008]

Uniprot Description

CCL19: May play a role not only in inflammatory and immunological responses but also in normal lymphocyte recirculation and homing. May play an important role in trafficking of T-cells in thymus, and T-cell and B-cell migration to secondary lymphoid organs. Specifically binds to chemokine receptor CCR7. Recombinant CCL19 shows potent chemotactic activity for T-cells and B-cells but not for granulocytes and monocytes. Belongs to the intercrine beta (chemokine CC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 9p13

Cellular Component: extracellular space; extracellular region

Molecular Function: CCR chemokine receptor binding; chemokine receptor binding; chemokine activity; CCR10 chemokine receptor binding; CCR7 chemokine receptor binding

Biological Process: formation of immunological synapse; positive regulation of interleukin-12 production; positive regulation of dendritic cell antigen processing and presentation; cell maturation; positive regulation of JNK cascade; positive regulation of NF-kappaB import into nucleus; positive regulation of endocytosis; positive regulation of interleukin-1 beta secretion; positive regulation of receptor-mediated endocytosis; activation of JNK activity; dendritic cell chemotaxis; cell communication; establishment of T cell polarity; positive regulation of T cell proliferation; inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of chemotaxis; response to virus; positive regulation of phosphoinositide 3-kinase activity; positive regulation of tumor necrosis factor production; cellular calcium ion homeostasis; positive regulation of protein kinase B signaling cascade; myeloid dendritic cell chemotaxis; release of sequestered calcium ion into cytosol; positive regulation of protein kinase activity; T cell costimulation; immune response; positive regulation of T-helper 1 cell differentiation