C-C Motif Chemokine 11/CCL11/Eotaxin Recombinant Protein | CCL11 recombinant protein

Recombinant Human C-C Motif Chemokine 11/CCL11/Eotaxin Protein

Cat. Num. AAA2552451

• Gene Names: CCL11; SCYA11
• Purity: >95% as determined by reducing SDS-PAGE.
• Synonyms: C-C Motif Chemokine 11/CCL11/Eotaxin; Recombinant Human C-C Motif Chemokine 11/CCL11/Eotaxin Protein; Eotaxin; C-C Motif Chemokine 11; Eosinophil Chemotactic Protein; Small-Inducible Cytokine A11; CCL11; SCYA11; CCL11 recombinant protein

• Host: E Coli
• Purity/Purification: >95% as determined by reducing SDS-PAGE.
• Form/Format: Lyophilized from a 0.2 mum filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
• Sequence Positions: Gly24-Pro97
• Sequence Length: 97

• Species: Human
• Endotoxin: <1.0 EU per ug as determined by LAL test.
• Preparation and Storage: Lyophilized protein should be stored at < -20 degree C, though stable at room temperature for 3 weeks.; Reconstituted protein solution can be stored at 4-7 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Related Product Information for CCL11 recombinant protein

C-C Motif Chemokine 11 (CCL11) is a secreted protein that belongs to the intercrine beta (chemokine CC) family. In response to the presence of allergens, CCL11 selectively recruits eosinophils, a prominent feature of allergic inflammatory reactions. The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine receptors for CCL11 include CCR2, CCR3 and CCR5. However, it has been found that CCL11 has high degree selectivity for its receptor, such that they are inactive on neutrophils and monocytes, which do not express CCR3.

NCBI and Uniprot Product Information

• NCBI GI #: 4506827
• NCBI GeneID: 6356
• NCBI Accession #: NP_002977.1
• NCBI GenBank Nucleotide #: NM_002986.2
• UniProt Accession #: P51671; P50877; Q92490; Q92491
• Molecular Weight: Molecular Mass: 8.6 kDa; Actual Protein Molecular Mass: 14 kDa
• NCBI Official Full Name: eotaxin
• NCBI Official Synonym Full Names: C-C motif chemokine ligand 11
• NCBI Official Symbol: CCL11
• NCBI Official Synonym Symbols: SCYA11
• NCBI Protein Information: eotaxin
• UniProt Protein Name: Eotaxin
• Protein Family: Eotaxin
• UniProt Gene Name: CCL11
• UniProt Synonym Gene Names: SCYA11

NCBI Description

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014]

Uniprot Description

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.