Human chromobox homolog 4 (Pc class homolog, Drosophila) ELISA Kit | CBX4 elisa kit
Human E3 SUMO-protein ligase CBX4, CBX4 ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 6.3.2.-; Transcription, coactivator/corepressor; SUMO ligase
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: nucleoplasm; nuclear speck; PcG protein complex; nucleus
Molecular Function: protein binding; enzyme binding; single-stranded RNA binding; SUMO binding; phosphoprotein binding; chromatin binding; transcription corepressor activity; methylated histone residue binding; ligase activity
Biological Process: protein sumoylation; transcription, DNA-dependent; chromatin modification; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; negative regulation of apoptosis
Research Articles on CBX4
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Product Notes
The Human CBX4 cbx4 (Catalog #AAA9330169) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9330169 ELISA Kit recognizes Human CBX4. It is sometimes possible for the material contained within the vial of "chromobox homolog 4 (Pc class homolog, Drosophila), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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