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Immunohistochemistry (IHC) (Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using Catenin-alpha1 antibody.)

Catenin-alpha1 Antibody | anti-CATNA1 antibody

Catenin-alpha1 (Ab-641) Antibody

Gene Names
CTNNA1; MDPT2; CAP102
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, ELISA
Purity
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Synonyms
Catenin-alpha1; Catenin-alpha1 (Ab-641) Antibody; 102 kDa cadherin-associated protein; Alpha E-catenin; CTN1; Cadherin-associated protein; catenin; alpha-1; anti-CATNA1 antibody
Ordering
For Research Use Only!
Reactivity
Human, Mouse, Rat
Specificity
Catenin-alpha1 antibody detects endogenous levels of total Catenin-alpha1 protein.
Purity/Purification
Affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Form/Format
In phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Sequence Length
841
Applicable Applications for anti-CATNA1 antibody
Immunohistochemistry (IHC), ELISA (EIA)
Application Notes
IHC: 1:50-1:100
ELISA: 1:5000
Immunogen
The antiserum was produced against synthesized peptide derived from Internal of human Catenin-alpha1.
Preparation and Storage
Store at-20 degree C for 1 year.

Immunohistochemistry (IHC)

(Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using Catenin-alpha1 antibody.)

Immunohistochemistry (IHC) (Peptide-+ Immunohistochemistry analysis of paraffin-embedded human brain tissue using Catenin-alpha1 antibody.)
References
Yutaka Shimoyama. Cancer Res., Oct 1992; 52: 5770-5774. Griet Vanpoucke. Nucleic Acids Res., Aug 2004; 32: 4155-4165. Jolanda van Hengel. J. Cell Biol., Jun 1997; 137: 1103.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
59,550 Da
NCBI Official Full Name
catenin alpha-1 isoform 2
NCBI Official Synonym Full Names
catenin alpha 1
NCBI Official Symbol
CTNNA1
NCBI Official Synonym Symbols
MDPT2; CAP102
NCBI Protein Information
catenin alpha-1
UniProt Protein Name
Catenin alpha-1
UniProt Gene Name
CTNNA1

NCBI Description

This gene encodes a member of the catenin family of proteins that play an important role in cell adhesion process by connecting cadherins located on the plasma membrane to the actin filaments inside the cell. The encoded mechanosensing protein contains three vinculin homology domains and undergoes conformational changes in response to cytoskeletal tension, resulting in the reconfiguration of cadherin-actin filament connections. Certain mutations in this gene cause butterfly-shaped pigment dystrophy. [provided by RefSeq, May 2016]

Uniprot Description

Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation.

Research Articles on CATNA1

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Product Notes

The CATNA1 ctnna1 (Catalog #AAA8502802) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Catenin-alpha1 (Ab-641) Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Catenin-alpha1 can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC), ELISA (EIA). IHC: 1:50-1:100 ELISA: 1:5000. Researchers should empirically determine the suitability of the CATNA1 ctnna1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Catenin-alpha1, Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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