Canine Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) ELISA Kit | CALCOCO1 elisa kit
Canine Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) ELISA Kit
NCBI and Uniprot Product Information
Uniprot Description
CALCOCO1: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. Belongs to the CALCOCO family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: intracellular membrane-bound organelle; nuclear chromatin; cytoplasm; nucleus
Molecular Function: protein C-terminus binding; protein binding; ligand-dependent nuclear receptor transcription coactivator activity; sequence-specific DNA binding; transcription coactivator activity; transcription cofactor activity; beta-catenin binding; chromatin binding
Biological Process: steroid hormone receptor signaling pathway; Wnt receptor signaling pathway; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of transcription from RNA polymerase II promoter; signal transduction