Rabbit CALCOCO1 Polyclonal Antibody | anti-CALCOCO1 antibody

CALCOCO1 Rabbit Polyclonal

Cat. Num. AAA767427

• Gene Names: CALCOCO1; Cocoa; PP13275; calphoglin
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: CALCOCO1; Polyclonal Antibody; CALCOCO1 Rabbit Polyclonal; anti-CALCOCO1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 691

• Applicable Applications for anti-CALCOCO1 antibody: ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Immunogen: Calcium binding and coiled-coil domain 1
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human kidney using MBS767427 (CALCOCO1 antibody) at dilution of 1:100)

Western Blot (WB)

(HT-1080 cells were subjected to SDS PAGE followed by western blot with MBS767427 (CALCOCO1 antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 14149742
• NCBI GeneID: 57658
• NCBI Accession #: NP_065949.1
• NCBI GenBank Nucleotide #: NM_020898.2
• Molecular Weight: 67,542 Da
• NCBI Official Full Name: calcium-binding and coiled-coil domain-containing protein 1 isoform 1
• NCBI Official Synonym Full Names: calcium binding and coiled-coil domain 1
• NCBI Official Symbol: CALCOCO1
• NCBI Official Synonym Symbols: Cocoa; PP13275; calphoglin
• NCBI Protein Information: calcium-binding and coiled-coil domain-containing protein 1
• UniProt Protein Name: Calcium-binding and coiled-coil domain-containing protein 1
• Protein Family: Calcium-binding and coiled-coil domain-containing protein
• UniProt Gene Name: CALCOCO1
• UniProt Synonym Gene Names: KIAA1536
• UniProt Entry Name: CACO1_HUMAN

Uniprot Description

CALCOCO1: Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1- mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. Belongs to the CALCOCO family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytoplasm; intracellular membrane-bound organelle; nuclear chromatin; nucleus

Molecular Function: beta-catenin binding; chromatin binding; ligand-dependent nuclear receptor transcription coactivator activity; protein binding; protein C-terminus binding; sequence-specific DNA binding; transcription coactivator activity; transcription cofactor activity

Biological Process: positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; signal transduction; steroid hormone receptor signaling pathway; transcription, DNA-dependent; Wnt receptor signaling pathway