SDS-Page
Interleukin-8 Recombinant Protein | CXCL8 recombinant protein
Interleukin-8, 23-99 aa, Human, E Coli
Gene Names
CXCL8; IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
Applications
SDS-Page
Purity
> 95% by SDS-PAGE
Synonyms
Interleukin-8; 23-99 aa; Human; E Coli; CXCL8; Neurophil chemotactic factor; NCF; Neutrophil activating protein; NAP; Monocyte derived neutrophil chemotactic factor; MDNCF; T-lymphocyte chemotactic factor; TCF; Granulocyte chemotactic protein; GCP; and Leukocyte adhension inhibitor; LAI; NAP 1; 3 10C; 310C; AMCF 1; AMCF1; b ENAP; Beta thromboglobulin like protein; CXC chemokine ligand 8; CXCL 8; Emoctakin; GCP 1; GCP1; Granulocyte chemotactic protein 1; IL 8; Inteleukin 8; Interleukin8; K 60; LECT; LuCT; Lymphocyte derived neutrophil activating factor; LYNAP; MDNCF a; MDNCF alpha; MONAP; Monocyte derived neutrophil activating protein; NAF; NAP1; Neutrophil activating factor; Neutrophil activating protein 1; Protein 3 10C; SCYB 8; SCYB8; T cell chemotactic factor; TSG 1; TSG1; il8; CXCL8 recombinant protein
Host
E Coli
Purity/Purification
> 95% by SDS-PAGE
Form/Format
Liquid. In phosphate buffer saline (pH 7.4)
Concentration
1 mg/ml (determined by BCA assay) (varies by lot)
Sequence
MAVLPRSAKE LRCQCIKTYS KPFHPKFIKE LRVIESGPHC ANTEIIVKLS DGRELCLDPK ENWVQRVVEK FLKRAENS
Sequence Length
99
Applicable Applications for CXCL8 recombinant protein
SDS-PAGE
Antigen Species
Human
Endotoxin Level
< 1.0 EU per 1 microgram of protein (determined by LAL method)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
SDS-Page
SDS-Page
Related Product Information for CXCL8 recombinant protein
Interleukin-8 (IL-8) is a chemokine, a member of the cytokine family that displays chemotactic activity for specific types of leukocytes. It is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. Many cell types, including monocyte/macrophages, T cells, neutrophils, fibroblasts, endothelial cells, keratinocytes, hepatocytes, chondrocytes, and various tumor cell lines, can produce CXCL8/IL-8 in response to a wide variety of pro-inflammatory stimuli such as exposure to IL-1, TNF, LPS, and viruses. Recombinant human IL-8 was expressed in E. coli and purified by using conventional chromatography techniques.
Product Categories/Family for CXCL8 recombinant protein
References
Mukaida, N., et al. (1992)Microbiol. Immunol. 36, 773-789 ; Larsen, C.G., et al. (1989). Science, 243, 1464-1466; Baldwin ET., et al. (1990). J Biol Chem. 265 (12):6851-6853 ;
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
9kDa (78aa), confirmed by MALDI-TOF.
NCBI Official Full Name
interleukin-8 isoform 1
NCBI Official Synonym Full Names
C-X-C motif chemokine ligand 8
NCBI Official Symbol
CXCL8
NCBI Official Synonym Symbols
IL8; NAF; GCP1; LECT; LUCT; NAP1; GCP-1; LYNAP; MDNCF; MONAP; NAP-1
NCBI Protein Information
interleukin-8
UniProt Protein Name
Interleukin-8
Protein Family
UniProt Gene Name
CXCL8
UniProt Synonym Gene Names
IL8; IL-8; GCP-1; MDNCF; MONAP; NAP-1; LYNAP; NAF
NCBI Description
The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is secreted primarily by neutrophils, where it serves as a chemotactic factor by guiding the neutrophils to the site of infection. This chemokine is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, Aug 2017]
Uniprot Description
IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.
Research Articles on CXCL8
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Product Notes
The CXCL8 cxcl8 (Catalog #AAA203086) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Interleukin-8 can be used in a range of immunoassay formats including, but not limited to, SDS-PAGE. Researchers should empirically determine the suitability of the CXCL8 cxcl8 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: MAVLPRSAKE LRCQCIKTYS KPFHPKFIKE LRVIESGPHC ANTEIIVKLS DGRELCLDPK ENWVQRVVEK FLKRAENS. It is sometimes possible for the material contained within the vial of "Interleukin-8, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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