Canine 5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS1) ELISA Kit | ALAS1 elisa kit

Canine 5-aminolevulinate synthase, nonspecific, mitochondrial (ALAS1) ELISA Kit

Cat. Num. AAA7238066

• Gene Names: ALAS1; ALAS; MIG4; ALAS3; ALASH
• Reactivity: Canine
• Synonyms: 5-aminolevulinate synthase; nonspecific; mitochondrial (ALAS1); Canine 5-aminolevulinate synthase; mitochondrial (ALAS1) ELISA Kit; ALAS1 elisa kit

• Reactivity: Canine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 40316939
• NCBI GeneID: 211
• NCBI Accession #: NP_954635.1
• NCBI GenBank Nucleotide #: NM_199166.2
• Molecular Weight: 12,961 Da
• NCBI Official Full Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
• NCBI Official Synonym Full Names: aminolevulinate, delta-, synthase 1
• NCBI Official Symbol: ALAS1
• NCBI Official Synonym Symbols: ALAS; MIG4; ALAS3; ALASH
• NCBI Protein Information: 5-aminolevulinate synthase, nonspecific, mitochondrial; ALAS-H; delta-ALA synthase 1; migration-inducing protein 4; 5-aminolevulinic acid synthase 1; delta-aminolevulinate synthase 1
• UniProt Protein Name: 5-aminolevulinate synthase, nonspecific, mitochondrial
• Protein Family: 5-aminolevulinate synthase
• UniProt Gene Name: ALAS1
• UniProt Synonym Gene Names: ALAS3; ALASH; OK/SW-cl.121; ALAS-H
• UniProt Entry Name: HEM1_HUMAN

NCBI Description

This gene encodes the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Uniprot Description

ALAS1: the mitochondrial enzyme which is catalyzes the rate-limiting step in heme (iron-protoporphyrin) biosynthesis. The enzyme encoded by this gene is the housekeeping enzyme; a separate gene encodes a form of the enzyme that is specific for erythroid tissue. The level of the mature encoded protein is regulated by heme: high levels of heme down-regulate the mature enzyme in mitochondria while low heme levels up-regulate. A pseudogene of this gene is located on chromosome 12. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Dec 2011]

Protein type: Transferase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Mitochondrial; Amino Acid Metabolism - glycine, serine and threonine; EC 2.3.1.37

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: nucleoplasm; mitochondrion; mitochondrial matrix; cytoplasm

Molecular Function: 5-aminolevulinate synthase activity; pyridoxal phosphate binding

Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; porphyrin metabolic process; cellular lipid metabolic process; protoporphyrinogen IX biosynthetic process; heme biosynthetic process