Cabin1 / Calcineurin-Binding Protein Cabin-1 Recombinant Protein | CABIN1 recombinant protein
Human Cabin1 / Calcineurin-Binding Protein Cabin-1 Recombinant Protein
Gene Names
CABIN1; CAIN; PPP3IN; KB-318B8.7
Applications
ELISA, Western Blot
Purity
>95% by SDS-PAGE
Synonyms
Cabin1 / Calcineurin-Binding Protein Cabin-1; Human Cabin1 / Calcineurin-Binding Protein Cabin-1 Recombinant Protein; Calcineurin-binding protein cabin-1; Calcineurin inhibitor; CAIN; KIAA0330; CABIN1 recombinant protein
Host
E Coli
Purity/Purification
>95% by SDS-PAGE
Form/Format
Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
Concentration
Reconstitution Dependent (varies by lot)
Sequence Length
2220
Applicable Applications for CABIN1 recombinant protein
ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
Species
Human
Tag
His
Subunit
Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.
Entry Function
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes.
Preparation and Storage
Store at -20 degree C. Avoid repeated freezing and thawing.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
calcineurin-binding protein cabin-1 isoform a
NCBI Official Synonym Full Names
calcineurin binding protein 1
NCBI Official Symbol
CABIN1
NCBI Official Synonym Symbols
CAIN; PPP3IN; KB-318B8.7
NCBI Protein Information
calcineurin-binding protein cabin-1
UniProt Protein Name
Calcineurin-binding protein cabin-1
Protein Family
UniProt Gene Name
CABIN1
UniProt Synonym Gene Names
KIAA0330; CAIN
UniProt Entry Name
CABIN_HUMAN
NCBI Description
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Research Articles on CABIN1
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Product Notes
The CABIN1 cabin1 (Catalog #AAA2903474) is a Recombinant Protein produced from E Coli and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Cabin1 / Calcineurin-Binding Protein Cabin-1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array. Researchers should empirically determine the suitability of the CABIN1 cabin1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Cabin1 / Calcineurin-Binding Protein Cabin-1, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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