Rabbit anti-Human, Rat CABIN1 Polyclonal Antibody | anti-CABIN1 antibody

CABIN1 Polyclonal Antibody

Cat. Num. AAA3007067

• Gene Names: CABIN1; CAIN; PPP3IN; KB-318B8.7
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: CABIN1; Polyclonal Antibody; CABIN1 Polyclonal Antibody; Calcineurin-binding protein cabin-1; Calcineurin inhibitor; CAIN; KIAA0330; anti-CABIN1 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: CABIN1 polyclonal antibody detects endogenous levels of CABIN1 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 2220

• Applicable Applications for anti-CABIN1 antibody: Western Blot (WB)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthetic peptide corresponding to residues in Human CABIN1.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of CABIN1 polyclonal antibody at 1:500 dilutionLane1:HEK293T whole cell lysateLane2:PC12 whole cell lysate)

Related Product Information for anti-CABIN1 antibody

Calcineurin binding protein (Cabin-1) and the corresponding rat homolog, designated Cain, are widely expressed nuclear phosphoproteins that regulate the serine/threonine phosphotase activity of calcineurin and influence T cell signaling and apoptosis. Calcineurin is required for the transcriptional activation of cytokines and the activation of various transcription factors, including NFAT, NFkappaB and AP-1, involved in T cell receptor (TCR)-mediated signaling. The regulation of calcineurin depends on the changes in intracellular calcium concentrations and the activity of protein kinase C. TCR activation results in PKC inducing the hyperphosphorylation of Cabin-1, which facilitates the high affinity binding of Cabin-1 to calcineurin. This complex formation, in turn, inhibits calcineurin activity and attenuates TCR-mediated signaling. Cabin-1 also associates directly with MEF-2 proteins, a family of transcription factors that regulate apoptosis signaling in T cells. This association between Cabin-1 and MEF-2 leads to the inhibition of MEF-2-mediated gene transcription and the inhibition of apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 313151181
• NCBI GeneID: 23523
• NCBI Accession #: NP_001186210.1
• NCBI GenBank Nucleotide #: NP_001186210.1
• UniProt Accession #: Q9Y6J0
• Molecular Weight: ~ 246kDa
• NCBI Official Full Name: calcineurin-binding protein cabin-1 isoform a
• NCBI Official Synonym Full Names: calcineurin binding protein 1
• NCBI Official Symbol: CABIN1
• NCBI Official Synonym Symbols: CAIN; PPP3IN; KB-318B8.7
• NCBI Protein Information: calcineurin-binding protein cabin-1
• UniProt Protein Name: Calcineurin-binding protein cabin-1
• Protein Family: Calcineurin-binding protein
• UniProt Gene Name: CABIN1
• UniProt Synonym Gene Names: KIAA0330; CAIN
• UniProt Entry Name: CABIN_HUMAN

NCBI Description

Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]