Rabbit anti-Human TAS2R38 Polyclonal Antibody | anti-TAS2R38 antibody

TAS2R38, CT (TAS2R38, PTC, Taste receptor type 2 member 38, PTC bitter taste receptor, Taste receptor type 2 member 61) (FITC)

Cat. Num. AAA6353713

• Gene Names: TAS2R38; PTC; T2R38; T2R61
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: TAS2R38; Polyclonal Antibody; CT (TAS2R38; PTC; Taste receptor type 2 member 38; PTC bitter taste receptor; Taste receptor type 2 member 61) (FITC); Taste receptor type 2 member 61; anti-TAS2R38 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-TAS2R38 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: TAS2R38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 304-332 amino acids from the C-terminal region of human TAS2R38.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(TAS2R38 Antibody (C-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the TAS2R38 antibody detected the TAS2R38 protein (arrow).)

Related Product Information for anti-TAS2R38 antibody

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant).

Product Categories/Family for anti-TAS2R38 antibody

Antibodies; Receptors

References

Reed, D.R., et al. Hum. Mol. Genet. 19(21):4278-4285(2010). Wendell, S., et al. J. Dent. Res. 89(11):1198-1202(2010). Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Wooding, S., et al. Chem. Senses 35(8):685-692(2010). Mennella, J.A., et al. BMC Genet. 11, 60 (2010).

NCBI and Uniprot Product Information

• NCBI GI #: 261490645
• NCBI GeneID: 5726
• NCBI Accession #: NP_789787.4
• NCBI GenBank Nucleotide #: NM_176817.4
• UniProt Accession #: P59533; P59552; Q2M3E8; Q645W3; Q86UK3; A4D1U6
• Molecular Weight: 37,892 Da
• NCBI Official Full Name: taste receptor type 2 member 38
• NCBI Official Synonym Full Names: taste 2 receptor member 38
• NCBI Official Symbol: TAS2R38
• NCBI Official Synonym Symbols: PTC; T2R38; T2R61
• NCBI Protein Information: taste receptor type 2 member 38
• UniProt Protein Name: Taste receptor type 2 member 38
• Protein Family: Taste receptor
• UniProt Gene Name: TAS2R38
• UniProt Synonym Gene Names: PTC; T2R38; T2R61

NCBI Description

This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]

Uniprot Description

Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5 ().