VPS39 blocking peptide

VPS39 Blocking Peptide

Cat. Num. AAA9621498

• Gene Names: VPS39; TLP; VAM6; hVam6p
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: VPS39; VPS39 Blocking Peptide; A230065P22Rik; AW743070; FLJ21681; FLJ46546; hVam6p; KIAA0770; RP23-348L16.12; TLP; TRAP1 like protein; Vacuolar protein sorting 39; Vacuolar protein sorting 39 homolog; VAM6; Vam6/Vps39 like; Vam6/Vps39 like protein; Vam6/Vps39-like protein; VPS 39; Vps39; VPS39_HUMAN; VPS39 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for VPS39 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for VPS39 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 33320680
• NCBI GeneID: 23339
• NCBI Accession #: AAQ05978
• NCBI GenBank Nucleotide #: NM_015289.3
• UniProt Accession #: Q96JC1; O94869; Q71SQ6; Q7Z3V3; Q96B93; Q96RM0
• Molecular Weight: 100,769 Da
• NCBI Official Full Name: vam6/Vps39-like protein isoform b
• NCBI Official Synonym Full Names: vacuolar protein sorting 39 homolog (S. cerevisiae)
• NCBI Official Symbol: VPS39
• NCBI Official Synonym Symbols: TLP; VAM6; hVam6p
• NCBI Protein Information: vam6/Vps39-like protein; TRAP1-like protein
• UniProt Protein Name: Vam6/Vps39-like protein
• Protein Family: Vam6/Vps39-like protein
• UniProt Gene Name: VPS39
• UniProt Synonym Gene Names: KIAA0770; TLP; VAM6; hVam6p
• UniProt Entry Name: VPS39_HUMAN

NCBI Description

This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta receptor complex to the Smad pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Uniprot Description

VPS39: May play a role in clustering and fusion of late endosomes and lysosomes. Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Belongs to the VAM6/VPS39 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, peripheral; G protein regulator, misc.

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: lysosomal membrane; late endosome membrane

Biological Process: vesicle-mediated transport; intracellular protein transport; regulation of catalytic activity