UCMA blocking peptide

UCMA Peptide

Cat. Num. AAA153198

• Gene Names: UCMA; GRP; C10orf49; GRP/UCMA
• Applications: Blocking (BL)
• Synonyms: UCMA; UCMA Peptide; GRP; C10orf49; Unique cartilage matrix-associated protein; Gla-rich protein; Ucma-C; upper zone of growth plate and cartilage matrix associated; UCMA blocking peptide

• Form/Format: Liquid
• Concentration: 200 ug/mL (varies by lot)
• Sequence Length: 138

• Applicable Applications for UCMA blocking peptide: Blocking (BL)
• Application Notes: UCMA peptide is used for blocking the activity of UCMA antibody.
• Species: Human
• Buffer: PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide
• Location: 17 amino acids near the carboxy terminus of human UCMA.
• Preparation and Storage: Store UCMA peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

• NCBI GI #: 50400088
• NCBI GeneID: 221044
• NCBI Accession #: NP_660357
• NCBI GenBank Nucleotide #: NM_145314.2
• UniProt Accession #: Q8WVF2
• Molecular Weight: 16,563 Da
• NCBI Official Full Name: unique cartilage matrix-associated protein isoform 1 preproprotein
• NCBI Official Synonym Full Names: upper zone of growth plate and cartilage matrix associated
• NCBI Official Symbol: UCMA
• NCBI Official Synonym Symbols: GRP; C10orf49; GRP/UCMA
• NCBI Protein Information: unique cartilage matrix-associated protein; Gla-rich protein
• UniProt Protein Name: Unique cartilage matrix-associated protein
• Protein Family: Unique cartilage matrix-associated protein
• UniProt Gene Name: UCMA
• UniProt Synonym Gene Names: C10orf49; Ucma-C; GRP
• UniProt Entry Name: UCMA_HUMAN

NCBI Description

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Uniprot Description

UCMA: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: extracellular space; proteinaceous extracellular matrix; perinuclear region of cytoplasm

Biological Process: negative regulation of osteoblast differentiation