Rabbit anti-Human, Mouse UCMA Polyclonal Antibody | anti-UCMA antibody

Rabbit Polyclonal to Human UCMA

Cat. Num. AAA243640

• Gene Names: UCMA; GRP; C10orf49; GRP/UCMA
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: UCMA; Polyclonal Antibody; Rabbit Polyclonal to Human UCMA; Anti-UCMA Antibody (C-Terminus) IHC-plus; C10orf49; Gla-rich protein; Human UCMA; anti-UCMA antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Human UCMA
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 138

• Applicable Applications for anti-UCMA antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IHC-P (5 ug/ml), WB (2.5 - 5 ug/ml); Usage: UCMA antibody can be used for detection of UCMA by Western blot at 2.5-5 ug/ml.
• Target Species: Human
• Immunogen Description: A 16 amino acid peptide near the carboxy terminus of human UCMA.
• Immunogen Type: Synthetic peptide
• Immunogen: UCMA antibody was raised against a 16 amino acid peptide near the carboxy terminus of human UCMA.
• Antigen Modification: C-Terminus
• Preparation and Storage: Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC)

(Anti-UCMA antibody IHC of human lung, chondrocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Western Blot (WB)

(Western blot of UCMA in SW1353 cell lysate with UCMA antibody at (A) 2.5 and (B) 5 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 50400088
• NCBI GeneID: 221044
• NCBI Accession #: NP_660357.2
• NCBI GenBank Nucleotide #: NM_145314.2
• UniProt Accession #: Q8WVF2
• Molecular Weight: 16,563 Da
• NCBI Official Full Name: unique cartilage matrix-associated protein isoform 1 preproprotein
• NCBI Official Synonym Full Names: upper zone of growth plate and cartilage matrix associated
• NCBI Official Symbol: UCMA
• NCBI Official Synonym Symbols: GRP; C10orf49; GRP/UCMA
• NCBI Protein Information: unique cartilage matrix-associated protein; Gla-rich protein
• UniProt Protein Name: Unique cartilage matrix-associated protein
• Protein Family: Unique cartilage matrix-associated protein
• UniProt Gene Name: UCMA
• UniProt Synonym Gene Names: C10orf49; Ucma-C; GRP
• UniProt Entry Name: UCMA_HUMAN

NCBI Description

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Uniprot Description

UCMA: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: extracellular space; proteinaceous extracellular matrix; perinuclear region of cytoplasm

Biological Process: negative regulation of osteoblast differentiation