Rabbit anti-Human UCMA Polyclonal Antibody | anti-UCMA antibody

UCMA Rabbit Polyclonal

Cat. Num. AAA7605458

• Gene Names: UCMA; GRP; C10orf49; GRP/UCMA
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Synonyms: UCMA; Polyclonal Antibody; UCMA Rabbit Polyclonal; anti-UCMA antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: >=95% as determined by SDS-PAGE; Immunogen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 106

• Applicable Applications for anti-UCMA antibody: ELISA (EIA), Western Blot (WB)
• Immunogen: Upper zone of growth plate and cartilage matrix associated
• Preparation and Storage: PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20 degree C for 24 months (Avoid repeated freeze / thaw cycles.)

Western Blot (WB)

(Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with MBS7605458 (UCMA Antibody) at dilution of 1:1000)

NCBI and Uniprot Product Information

• NCBI GI #: 733606285
• NCBI GeneID: 221044
• NCBI Accession #: NP_001290047.1
• NCBI GenBank Nucleotide #: NM_001303118.1
• Molecular Weight: 16,563 Da
• NCBI Official Full Name: unique cartilage matrix-associated protein isoform 2
• NCBI Official Synonym Full Names: upper zone of growth plate and cartilage matrix associated
• NCBI Official Symbol: UCMA
• NCBI Official Synonym Symbols: GRP; C10orf49; GRP/UCMA
• NCBI Protein Information: unique cartilage matrix-associated protein
• UniProt Protein Name: Unique cartilage matrix-associated protein
• Protein Family: Unique cartilage matrix-associated protein
• UniProt Gene Name: UCMA
• UniProt Synonym Gene Names: C10orf49; Ucma-C; GRP
• UniProt Entry Name: UCMA_HUMAN

NCBI Description

This gene encodes a chondrocyte-specific, highly charged protein that is abundantly expressed in the upper immature zone of fetal and juvenile epiphyseal cartilage. The encoded protein undergoes proteolytic processing to generate a mature protein that is secreted into the extracellular matrix. The glutamic acid residues in the encoded protein undergo gamma carboxylation in a vitamin K-dependent manner. Undercarboxylation of the encoded protein is associated with osteoarthritis in humans. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2015]

Uniprot Description

UCMA: May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface. Belongs to the UCMA family.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: extracellular space; perinuclear region of cytoplasm; proteinaceous extracellular matrix

Biological Process: negative regulation of osteoblast differentiation