Tfap2a blocking peptide

Mouse Tfap2a Blocking Peptide (Center)

• Synonyms: Tfap2a; Mouse Tfap2a Blocking Peptide (Center); Transcription factor AP-2-alpha; AP2-alpha; AP-2 transcription factor; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2; Ap2tf; Tcfap2a; Tfap2a blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 154-166 of HUMAN Tfap2a
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 437

• Cellular Location: Nucleus.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Tfap2a blocking peptide

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

NCBI and Uniprot Product Information

• NCBI GI #: 146286031
• NCBI GeneID: 505849
• UniProt Accession #: P34056; Q60740; Q60741; Q60742; Q60743; Q62067; Q62068; Q62069; Q91VX0; Q9CRY4; A1A4R9
• Molecular Weight: 50,900 Da
• NCBI Official Full Name: Transcription factor AP-2-alpha
• NCBI Official Symbol: TFAP2A
• NCBI Protein Information: transcription factor AP-2-alpha
• UniProt Protein Name: Transcription factor AP-2-alpha
• Protein Family: Transcription factor
• UniProt Gene Name: Tfap2a
• UniProt Synonym Gene Names: Ap2tf; Tcfap2a; AP2-alpha; AP-2
• UniProt Entry Name: AP2A_MOUSE

Uniprot Description

AP-2 alpha: Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region. Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members. Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with RALBP1 in a complex also containing EPN1 and NUMB during interphase and mitosis. Interacts with KCTD1; this interaction represses transcription activation. Interacts (via C-terminus) with CITED2 (via C-terminus); the interaction stimulates TFAP2A- transcriptional activation. Interacts (via N-terminus) with EP300 (via N-terminus); the interaction requires CITED2. Belongs to the AP-2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Cellular Component: centrosome; cytoplasm; cytosol; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm; nucleus; transcription factor complex

Molecular Function: chromatin binding; protein binding; protein dimerization activity; sequence-specific DNA binding; transcription coactivator activity; transcription factor activity; transcription factor binding

Biological Process: anterior neuropore closure; embryonic body morphogenesis; embryonic camera-type eye morphogenesis; embryonic cranial skeleton morphogenesis; embryonic forelimb morphogenesis; embryonic pattern specification; epidermis morphogenesis; forebrain neuron development; forelimb morphogenesis; inner ear morphogenesis; kidney development; lens morphogenesis in camera-type eye; negative regulation of apoptosis; negative regulation of cell proliferation; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of neuron apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neural crest cell development; neural tube closure; oculomotor nerve formation; palate development; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of neuron apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of cell differentiation; regulation of neuron differentiation; regulation of transcription from RNA polymerase II promoter; regulation of transcription, DNA-dependent; response to lipopolysaccharide; sensory perception of sound; skeletal morphogenesis; skin development; sympathetic nervous system development; trigeminal nerve development