AP-2 Antibody | anti-AP-2 antibody

AP-2 Antibody

Cat. Num. AAA8510961

• Gene Names: TFAP2A; AP-2; BOFS; AP2TF; TFAP2; AP-2alpha
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: Immunogen affinity purified
• Synonyms: AP-2; AP-2 Antibody; Activating enhancer-binding protein 2-alpha; Activator protein 2; AP-2 transcription factor; AP-2alpha; AP2-alpha; AP2A; AP2TF; BOFS; FLJ51761; TFAP2; TFAP2A; transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha); Transcript; anti-AP-2 antibody

• Reactivity: Human, Mouse, Rat
• Specificity: AP-2 Antibody detects endogenous levels of AP-2
• Purity/Purification: Immunogen affinity purified
• Form/Format: In phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Sequence Length: 431

• Applicable Applications for anti-AP-2 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:2000; IHC: 1:50-1:200
• Immunogen: A synthesized peptide derived from human AP-2
• Preparation and Storage: Store at-20 degree C for 1 year

Western Blot (WB)

(Western blot analysis on COLO205 cell lysate using AP-2 Antibody)

Related Product Information for anti-AP-2 antibody

AP-2 alpha Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.

NCBI and Uniprot Product Information

• NCBI GI #: 73760407
• NCBI GeneID: 7020
• NCBI Accession #: NP_001027451.1
• NCBI GenBank Nucleotide #: NM_001032280.2
• UniProt Accession #: P05549; Q13777; Q5TAV5; Q8N1C6
• Molecular Weight: 49kDa
• NCBI Official Full Name: transcription factor AP-2-alpha isoform b
• NCBI Official Synonym Full Names: transcription factor AP-2 alpha
• NCBI Official Symbol: TFAP2A
• NCBI Official Synonym Symbols: AP-2; BOFS; AP2TF; TFAP2; AP-2alpha
• NCBI Protein Information: transcription factor AP-2-alpha
• UniProt Protein Name: Transcription factor AP-2-alpha
• Protein Family: AP-2 complex
• UniProt Gene Name: TFAP2A
• UniProt Synonym Gene Names: AP2TF; TFAP2; AP2-alpha; AP-2

NCBI Description

The protein encoded by this gene is a transcription factor that binds the consensus sequence 5'-GCCNNNGGC-3'. The encoded protein functions as either a homodimer or as a heterodimer with similar family members. This protein activates the transcription of some genes while inhibiting the transcription of others. Defects in this gene are a cause of branchiooculofacial syndrome (BOFS). Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2009]

Uniprot Description

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. AP-2-alpha is the only AP-2 protein required for early morphogenesis of the lens vesicle. Together with the CITED2 coactivator, stimulates the PITX2 P1 promoter transcription activation. Associates with chromatin to the PITX2 P1 promoter region.