STX17 blocking peptide
STX17 Antibody (N-term) Blocking peptide
Synonyms
STX17; STX17 Antibody (N-term) Blocking peptide; Syntaxin-17; STX17 blocking peptide
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of STX17. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
302
Cellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein. Smooth endoplasmic reticulum membrane; Multi-pass membrane protein Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII- coated vesicle membrane; Multi-pass membrane protein. Cytoplasm, cytosol. Note: Has an hairpin-like insertion into membranes. Localized into endoplasmic reticulum membranes, it also localizes to the completed autophagosome membrane upon cell starvation. May also localize to the mitochondria according to PubMed:23217709. A significant amount is also present in the cytosol
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for STX17 blocking peptide
SNAREs, Soluble N-ethylmaleimide-sensitive factor- attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. STX17 is a SNARE of the autophagosome involved in autophagy through the direct control of autophagosome membrane fusion with the lysosome membrane. May also play a role in the early secretory pathway where it may maintain the architecture of the endoplasmic reticulum-Golgi intermediate compartment/ERGIC and Golgi and/or regulate transport between the endoplasmic reticulum, the ERGIC and the Golgi (PubMed:21545355).
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
33,403 Da
NCBI Official Full Name
Syntaxin-17
NCBI Official Synonym Full Names
syntaxin 17
NCBI Official Symbol
STX17
NCBI Protein Information
syntaxin-17
UniProt Protein Name
Syntaxin-17
Protein Family
UniProt Gene Name
STX17
UniProt Entry Name
STX17_HUMAN
Uniprot Description
STX17: Implicated in vesicle trafficking to lysosomes. Could be involved in processes related to cell division. Belongs to the syntaxin family.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Vesicle
Chromosomal Location of Human Ortholog: 9q31.1
Cellular Component: cytosol; endoplasmic reticulum membrane; ER to Golgi transport vesicle; ER-Golgi intermediate compartment; integral to membrane; lysosomal membrane; mitochondrion; rough endoplasmic reticulum; smooth endoplasmic reticulum membrane; SNARE complex
Molecular Function: protein binding; protein phosphatase binding; SNAP receptor activity; SNARE binding
Biological Process: ER to Golgi vesicle-mediated transport; Golgi organization and biogenesis; intracellular protein transport; vesicle docking; vesicle fusion
Research Articles on STX17
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Product Notes
The STX17 stx17 (Catalog #AAA9220041) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "STX17, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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