RYBP blocking peptide
RYBP Peptide
Target Description: RYBP contains 1 RanBP2-type zinc finger. RYBP may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. In tumor cell lines, it may induce apoptosis.
NCBI and Uniprot Product Information
Uniprot Description
RYBP: Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. May bind to DNA. Promotes apoptosis.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 3p13
Cellular Component: nucleoplasm; cytoplasm; PcG protein complex
Molecular Function: protein binding; DNA binding; zinc ion binding; transcription corepressor activity
Biological Process: transcription, DNA-dependent; apoptosis; multicellular organismal development; negative regulation of transcription from RNA polymerase II promoter