RNF11 blocking peptide

RNF11 Antibody (Center) Blocking peptide

• Gene Names: RNF11; CGI-123; SID1669
• Synonyms: RNF11; RNF11 Antibody (Center) Blocking peptide; RING finger protein 11; RNF11 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 154

• Cellular Location: Early endosome. Recycling endosome. Cytoplasm. Nucleus. Note: Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1
• Tissue Location: Expressed at low levels in the lung, liver, kidney, pancreas, spleen, prostate, thymus, ovary, small intestine, colon, and peripheral blood lymphocytes, and, at intermediate levels, in the testis, heart, brain and placenta Highest expression in the skeletal muscle. In the brain, expressed at different levels in several regions: high levels in the amygdala, moderate in the hippocampus and thalamus, low in the caudate and extremely low levels in the corpus callosum (at protein level). Restricted to neurons, enriched in somatodendritic compartments and excluded from white matter (at protein level). In substantia nigra, present in cell bodies and processes of dopaminergic and nondopaminergic cells (at protein level). In Parkinson disease, sequestered in Lewy bodies and neurites Overexpressed in breast cancer cells, but not detected in the surrounding stroma and weakly, if at all, in normal breast epithelial cells (at protein level). Also expressed in several tumor cell lines.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RNF11 blocking peptide

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

NCBI and Uniprot Product Information

• NCBI GI #: 21362884
• NCBI GeneID: 26994
• UniProt Accession #: Q9Y3C5; Q5T7R8; A8KAI2
• Molecular Weight: 17,444 Da
• NCBI Official Full Name: RING finger protein 11
• NCBI Official Synonym Full Names: ring finger protein 11
• NCBI Official Symbol: RNF11
• NCBI Official Synonym Symbols: CGI-123; SID1669
• NCBI Protein Information: RING finger protein 11
• UniProt Protein Name: RING finger protein 11
• Protein Family: RING finger protein
• UniProt Gene Name: RNF11
• UniProt Entry Name: RNF11_HUMAN

NCBI Description

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

Uniprot Description

RNF11: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Protein type: EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: ubiquitin ligase complex

Molecular Function: DNA binding; protein binding; ubiquitin-protein ligase activity

Biological Process: protein autoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process