Rabbit anti-Human RNF11 Polyclonal Antibody | anti-RNF11 antibody

RNF11 Antibody

Cat. Num. AAA7044593

• Gene Names: RNF11; CGI-123; SID1669
• Reactivity: Human
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen Affinity Purified
• Synonyms: RNF11; Polyclonal Antibody; RNF11 Antibody; RING finger protein 11; CGI-123; anti-RNF11 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen Affinity Purified
• Form/Format: Liquid
• Sequence Length: 154

• Applicable Applications for anti-RNF11 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: Recommended dilution: IHC: 1:20-1:200
• Species: Human
• Immunogen: Recombinant human RING finger protein 11 protein (1-154AA)
• Conjugate: Non-conjugated
• Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
• Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-160748
• Preparation and Storage: Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human thyroid tissue using MBS7044593 at dilution of 1:100)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human colon cancer using MBS7044593 at dilution of 1:100)

Related Product Information for anti-RNF11 antibody

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

NCBI and Uniprot Product Information

• NCBI GI #: 7657520
• NCBI GeneID: 26994
• NCBI Accession #: NP_055187.1
• NCBI GenBank Nucleotide #: NM_014372.4
• UniProt Accession #: Q9Y3C5; Q5T7R8; A8KAI2
• Molecular Weight: 17,444 Da
• NCBI Official Full Name: RING finger protein 11
• NCBI Official Synonym Full Names: ring finger protein 11
• NCBI Official Symbol: RNF11
• NCBI Official Synonym Symbols: CGI-123; SID1669
• NCBI Protein Information: RING finger protein 11
• UniProt Protein Name: RING finger protein 11
• Protein Family: RING finger protein
• UniProt Gene Name: RNF11
• UniProt Entry Name: RNF11_HUMAN

NCBI Description

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]

Uniprot Description

RNF11: Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Protein type: Ligase; Ubiquitin conjugating system; EC 6.3.2.-; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 1p32

Cellular Component: ubiquitin ligase complex

Molecular Function: DNA binding; protein binding; ubiquitin-protein ligase activity

Biological Process: protein autoubiquitination; protein ubiquitination during ubiquitin-dependent protein catabolic process