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RGS19 blocking peptide

RGS19 Antibody (N-term) Blocking Peptide

Gene Names
RGS19; GAIP; RGSGAIP
Synonyms
RGS19; RGS19 Antibody (N-term) Blocking Peptide; Regulator of G-protein signaling 19; G-alpha-interacting protein; GAIP; GNAI3IP; RGS19 blocking peptide
Ordering
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the N-term region of human Autophagy RGS19. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
Sequence Length
217
Cellular Location
Membrane; Lipid-anchor.
Tissue Location
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for RGS19 blocking peptide
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
24,636 Da
NCBI Official Full Name
Regulator of G-protein signaling 19
NCBI Official Synonym Full Names
regulator of G-protein signaling 19
NCBI Official Symbol
RGS19
NCBI Official Synonym Symbols
GAIP; RGSGAIP
NCBI Protein Information
regulator of G-protein signaling 19
UniProt Protein Name
Regulator of G-protein signaling 19
UniProt Gene Name
RGS19
UniProt Synonym Gene Names
GAIP; GNAI3IP; RGS19; GAIP
UniProt Entry Name
RGS19_HUMAN

NCBI Description

G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

RGS19: inhibits signal transduction by increasing the GTPase activity of g protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(I)a3 > G(I)a1 > G(O)a >> G(Z)a/G(I)a2. Activity on G(Z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.

Protein type: GAPs, RGS; GAPs

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: beta-catenin destruction complex; cell cortex; cytoplasmic membrane-bound vesicle; cytoplasmic microtubule; Golgi apparatus; heterotrimeric G-protein complex; membrane; postsynaptic density

Molecular Function: beta-catenin binding; GTPase activator activity; protein binding; protein kinase binding

Biological Process: cell death; cell differentiation; dorsal/ventral axis specification; G-protein coupled receptor protein signaling pathway; regulation of transcription, DNA-dependent; small GTPase mediated signal transduction

Research Articles on RGS19

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Product Notes

The RGS19 rgs19 (Catalog #AAA9223236) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RGS19, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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