RAPGEF1 blocking peptide

RAPGEF1 Blocking Peptide (Center)

• Gene Names: RAPGEF1; C3G; GRF2
• Synonyms: RAPGEF1; RAPGEF1 Blocking Peptide (Center); Rap guanine nucleotide exchange factor 1; CRK SH3-binding GNRP; Guanine nucleotide-releasing factor 2; Protein C3G; GRF2; RAPGEF1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 536-549 of HUMAN RAPGEF1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 1077

• Cellular Location: Early endosome
• Tissue Location: Ubiquitously expressed in adult and fetus. Expression is high in adult skeletal muscle and placenta and in fetal brain and heart. Low levels of expression in adult and fetal liver
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RAPGEF1 blocking peptide

Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS. Plays a role in the establishment of basal endothelial barrier function. Plays a role in nerve growth factor (NGF)-induced sustained activation of Rap1 and neurite outgrowth.

NCBI and Uniprot Product Information

• NCBI GI #: 143811452
• NCBI GeneID: 2889
• UniProt Accession #: Q13905; Q5JUE4; Q68DL3; Q8IV73
• Molecular Weight: 122,287 Da
• NCBI Official Full Name: Rap guanine nucleotide exchange factor 1
• NCBI Official Synonym Full Names: Rap guanine nucleotide exchange factor 1
• NCBI Official Symbol: RAPGEF1
• NCBI Official Synonym Symbols: C3G; GRF2
• NCBI Protein Information: rap guanine nucleotide exchange factor 1
• UniProt Protein Name: Rap guanine nucleotide exchange factor 1
• Protein Family: Rap guanine nucleotide exchange factor
• UniProt Gene Name: RAPGEF1
• UniProt Synonym Gene Names: GRF2
• UniProt Entry Name: RPGF1_HUMAN

NCBI Description

This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Description

RAPGEF1: an adaptor-type Src homology (SH)2-containing molecule. A guanine nucleotide releasing protein for Ras. Expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants have been described.

Protein type: GEFs; GEFs, Ras; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: cytosol; early endosome; endosome

Molecular Function: protein binding; Rap guanyl-nucleotide exchange factor activity

Biological Process: activation of MAPKK activity; positive regulation of GTPase activity; Rap protein signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway