Rab17 blocking peptide
Mouse Rab17 Antibody (Center) Blocking Peptide
Gene Names
Rab17; AW413472
Synonyms
Rab17; Mouse Rab17 Antibody (Center) Blocking Peptide; Ras-related protein Rab-17; Rab17 blocking peptide
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
214
Cellular Location
Recycling endosome membrane; Lipid-anchor; Cytoplasmic side. Cell projection, dendrite. Note: According to a report the protein is localized at the basolateral and apical plasma membrane of kidney epithelial cells (PubMed:8486736). It was later shown to localize to the apical recycling endosome in epithelial cells (PubMed:21291502). In neurons, localizes to the cell body and dendritic shaft and spine
Tissue Location
Expressed in kidney, liver, and intestine mainly by epithelial cells. Expressed in hippocampus (at protein level).
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for Rab17 blocking peptide
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post- endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development. May also play a role in cell migration.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
23,640 Da
NCBI Official Full Name
Ras-related protein Rab-17
NCBI Official Synonym Full Names
RAB17, member RAS oncogene family
NCBI Official Symbol
Rab17
NCBI Official Synonym Symbols
AW413472
NCBI Protein Information
ras-related protein Rab-17
UniProt Protein Name
Ras-related protein Rab-17
Protein Family
UniProt Gene Name
Rab17
UniProt Entry Name
RAB17_MOUSE
Uniprot Description
RAB17: Might be involved in transcellular transport. Belongs to the small GTPase superfamily. Rab family.
Protein type: G protein, monomeric, Rab; G protein, monomeric; G protein
Cellular Component: apical plasma membrane; basolateral plasma membrane; cell soma; dendrite; early endosome; endocytic vesicle; intracellular; melanosome; recycling endosome; recycling endosome membrane
Molecular Function: GDP binding; GTPase activity; protein binding
Biological Process: cilium biogenesis; endocytic recycling; endocytosis; establishment of melanosome localization; filopodium formation; immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor; melanosome transport; regulation of dendrite development; regulation of filopodium formation; regulation of synaptogenesis; transcytosis
Research Articles on Rab17
Similar Products
Product Notes
The Rab17 rab17 (Catalog #AAA9223683) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Rab17, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
