PRSS8 blocking peptide

PRSS8 Antibody (Center) Blocking Peptide

• Gene Names: PRSS8; CAP1; PROSTASIN
• Synonyms: PRSS8; PRSS8 Antibody (Center) Blocking Peptide; Prostasin; 3421-; Channel-activating protease 1; CAP1; Serine protease 8; Prostasin light chain; Prostasin heavy chain; PRSS8 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 343

• Cellular Location: Prostasin: Cell membrane; Single-pass membrane protein Prostasin heavy chain: Secreted, extracellular space. Note: Found in the seminal fluid. Secreted after cleavage of its C-terminus
• Tissue Location: Found in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus and renal proximal tubular cells. In the prostate gland it may be synthesized in epithelial cells, secreted into the ducts, and excreted into the seminal fluid
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PRSS8 blocking peptide

Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G).

NCBI and Uniprot Product Information

• NCBI GI #: 2833277
• NCBI GeneID: 5652
• UniProt Accession #: Q16651; Q9UCA3; B4DWP2
• Molecular Weight: 30,519 Da
• NCBI Official Full Name: Prostasin
• NCBI Official Synonym Full Names: protease, serine 8
• NCBI Official Symbol: PRSS8
• NCBI Official Synonym Symbols: CAP1; PROSTASIN
• NCBI Protein Information: prostasin
• UniProt Protein Name: Prostasin
• Protein Family: Prostasin
• UniProt Gene Name: PRSS8
• UniProt Synonym Gene Names: CAP1
• UniProt Entry Name: PRSS8_HUMAN

NCBI Description

This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

Uniprot Description

PRSS8: Possesses a trypsin-like cleavage specificity with a preference for poly-basic substrates. Stimulates epithelial sodium channel (ENaC) activity through activating cleavage of the gamma subunits (SCNN1G). Belongs to the peptidase S1 family.

Protein type: Protease; Membrane protein, integral; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function: protein binding; serine-type peptidase activity