PPP1R13L blocking peptide

PPP1R13L Blocking Peptide (Center)

• Gene Names: PPP1R13L; RAI; RAI4; IASPP; NKIP1
• Synonyms: PPP1R13L; PPP1R13L Blocking Peptide (Center); RelA-associated inhibitor; Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein; IASPP; NKIP1; PPP1R13BL; RAI; PPP1R13L blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 455-465 of HUMAN PPP1R13L
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 828

• Cellular Location: Cytoplasm. Nucleus. Note: Predominantly cytoplasmic but also nuclear
• Tissue Location: Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PPP1R13L blocking peptide

Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis.

NCBI and Uniprot Product Information

• NCBI GI #: 92090607
• NCBI GeneID: 10848
• UniProt Accession #: Q8WUF5; Q2PNZ9; Q5DU71; Q5I1X4; Q6P1R7; Q6PKF8; Q9Y290
• Molecular Weight: 89,091 Da
• NCBI Official Full Name: RelA-associated inhibitor
• NCBI Official Synonym Full Names: protein phosphatase 1 regulatory subunit 13 like
• NCBI Official Symbol: PPP1R13L
• NCBI Official Synonym Symbols: RAI; RAI4; IASPP; NKIP1
• NCBI Protein Information: relA-associated inhibitor
• UniProt Protein Name: RelA-associated inhibitor
• Protein Family: RelA-associated inhibitor
• UniProt Gene Name: PPP1R13L
• UniProt Synonym Gene Names: IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP
• UniProt Entry Name: IASPP_HUMAN

NCBI Description

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

Uniprot Description

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear.

Protein type: Phosphatase, regulatory subunit; Apoptosis; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cell junction; cytoplasm; intercellular bridge; nucleoplasm; nucleus

Molecular Function: identical protein binding; protein binding; transcription corepressor activity