Rabbit Cadherin-7 Polyclonal Antibody | anti-R678 antibody

Cadherin-7 (R678) Polyclonal Antibody

Cat. Num. AAA3002318

• Gene Names: CDH7; CDH7L1
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: Cadherin-7; Polyclonal Antibody; Cadherin-7 (R678) Polyclonal Antibody; CDH7; CDH7L1; anti-R678 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Cadherin-7 (R678) polyclonal antibody detects endogenous levels of Cadherin-7 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 785

• Applicable Applications for anti-R678 antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: WB: 1:500-1:1000; IHC: 1:50-1:200
• Immunogen: Synthetic peptide, corresponding to amino acids 645-693 of Human Cadherin-7.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of Cadherin-7 (R678) pAb at 1:500 dilutionLane1:The Brain tissue lysate of Mouse (40ug) Lane2:The Brain tissue lysate of Rat (40ug))

Immunohistochemistry (IHC)

(Immunohistochemistry (IHC) analyzes of Cadherin-7 (R678) pAb in paraffin-embedded human colorectal carcinoma tissue at 1:50.)

Related Product Information for anti-R678 antibody

The cadherins are a family of Ca2+-dependent adhesion molecules that function to mediate cell-cell binding critical to the maintenance of structure and morphogenesis. Cadherins each contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. Cadherin-7 is a member of the atypical type II cadherin family that lacks the HAV cell recognition sequence found in type I cadherins. Although the absence of an HAV sequence decreases cell adhesion specificity, cadherin-7 contributes to cell organization by mediating homophilic cell adhesion in the brain, testis and prostate.

NCBI and Uniprot Product Information

• NCBI GI #: 16306489
• NCBI GeneID: 1005
• NCBI Accession #: NP_004352.2
• NCBI GenBank Nucleotide #: NP_004352.2
• UniProt Accession #: Q9ULB5
• Molecular Weight: ~ 87kDa
• NCBI Official Full Name: cadherin-7 isoform 1 preproprotein
• NCBI Official Synonym Full Names: cadherin 7
• NCBI Official Symbol: CDH7
• NCBI Official Synonym Symbols: CDH7L1
• NCBI Protein Information: cadherin-7
• UniProt Protein Name: Cadherin-7
• Protein Family: Cadherin
• UniProt Gene Name: CDH7
• UniProt Synonym Gene Names: CDH7L1
• UniProt Entry Name: CADH7_HUMAN

NCBI Description

This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types. Mutations in this gene may be associated with bipolar disease in human patients. This gene is present in a gene cluster on chromosome 18. [provided by RefSeq, May 2016]

Uniprot Description

CDH7: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Protein type: Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 18q22.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: calcium ion binding

Biological Process: intercellular junction assembly and maintenance; cell-cell adhesion; homophilic cell adhesion