PNPLA2 blocking peptide

PNPLA2 Blocking Peptide (N-term)

• Gene Names: PNPLA2; ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
• Synonyms: PNPLA2; PNPLA2 Blocking Peptide (N-term); Patatin-like phospholipase domain-containing protein 2; Adipose triglyceride lipase; Calcium-independent phospholipase A2; Desnutrin; IPLA2-zeta; Pigment epithelium-derived factor; TTS22; Transport-secretion protein 2; TTS2; ATGL; PNPLA2 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 504

• Cellular Location: Lipid droplet. Cell membrane; Single-pass type II membrane protein
• Tissue Location: Highest expression in adipose tissue. Also detected in heart, skeletal muscle, and portions of the gastrointestinal tract. Detected in normal retina and retinoblastoma cells. Detected in retinal pigment epithelium and, at lower intensity, in the inner segments of photoreceptors and in the ganglion cell layer of the neural retina (at protein level)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PNPLA2 blocking peptide

Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Also has acylglycerol transacylase activity. May act coordinately with LIPE/HLS within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion.

NCBI and Uniprot Product Information

• NCBI GI #: 74731110
• NCBI GeneID: 57104
• UniProt Accession #: Q96AD5; O60643; Q5EFF5; Q6XYE5; Q96ET6; Q9NQ61; Q9NQ62
• Molecular Weight: 19,875 Da
• NCBI Official Full Name: Patatin-like phospholipase domain-containing protein 2
• NCBI Official Synonym Full Names: patatin like phospholipase domain containing 2
• NCBI Official Symbol: PNPLA2
• NCBI Official Synonym Symbols: ATGL; TTS2; PEDF-R; FP17548; TTS-2.2; iPLA2zeta; 1110001C14Rik
• NCBI Protein Information: patatin-like phospholipase domain-containing protein 2
• UniProt Protein Name: Patatin-like phospholipase domain-containing protein 2
• Protein Family: Patatin-like phospholipase domain-containing protein
• UniProt Gene Name: PNPLA2
• UniProt Synonym Gene Names: ATGL; TTS2
• UniProt Entry Name: PLPL2_HUMAN

NCBI Description

This gene encodes an enzyme which catalyzes the first step in the hydrolysis of triglycerides in adipose tissue. Mutations in this gene are associated with neutral lipid storage disease with myopathy. [provided by RefSeq, Jul 2010]

Uniprot Description

PNPLA2: the rate-limiting lipolytic enzyme in mammals, flies, and yeast. Catalyzes the initial step in triglyceride hydrolysis in adipocyte and non-adipocyte lipid droplets. Upregulated by exercise training in human skeletal muscle. Has acylglycerol transacylase activity. May act coordinately with HSL within the lipolytic cascade. Regulates adiposome size and may be involved in the degradation of adiposomes. May play an important role in energy homeostasis. May play a role in the response of the organism to starvation, enhancing hydrolysis of triglycerides and providing free fatty acids to other tissues to be oxidized in situations of energy depletion. Interacting with ABHD5 stimulates its triglyceride hydrolase activity. Despite a colocalization in lipid droplets, it probably does not interact with perilipin. Transcriptionally regulated by FOXO1A. Defects cause neutral lipid storage disease (NLSD), an autosomal recessive disorder characterized by the excessive accumulation of neutral lipids in multiple tissues. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Lipase; EC 3.1.1.3

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: endoplasmic reticulum membrane; lipid particle

Molecular Function: acylglycerol O-acyltransferase activity; lipoprotein lipase activity; triacylglycerol lipase activity

Disease: Neutral Lipid Storage Disease With Myopathy