PKAgamma cat Blocking Peptide | PKAgamma blocking peptide

PKAgamma cat (P5) Peptide

Cat. Num. AAA3001936

• Gene Names: PRKACG; KAPG; PKACg; BDPLT19
• Applications: Blocking
• Purity: Synthetic peptide PKAgamma cat (P5). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: PKAgamma cat; PKAgamma cat (P5) Peptide; cAMP-dependent protein kinase catalytic subunit gamma; KAPCG; KAPG; PKA C gamma; PKA C-gamma; PKACg; PRKACG; Protein kinase cAMP dependent catalytic gamma; Serine (threonine) protein kinase; PKAgamma blocking peptide

• Specificity: This peptide can be used with studies using MBS3001935 PKAgamma cat (P5) pAb.
• Purity/Purification: Synthetic peptide PKAgamma cat (P5). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 351

• Applicable Applications for PKAgamma blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for PKAgamma blocking peptide

Activation of PKA occurs when cAMP binds to the two regulatory subunits of the tetrameric PKA holoenzyme resulting in release of active catalytic subunits. Three catalytic (C) subunits have been identified, designated Calpha, Cbeta and Cgamma, that each represent specific gene products. Calpha and Cbeta are closely related (93% amino acid sequence similarity), whereas Cgamma displays 83% and 79% similarity to Calpha and Cbeta, respectively. Activation of transcription upon elevation of cAMP levels results from translocation of PKA to the nucleus where it phosphorylates the transcription factor cAMP response element binding protein (CREB) on serine 133 which in turn leads to TFIIB binding to TATA-box-binding protein TBP1, thus linking phospho-CREB to the Pol II transcription initiation complex.

NCBI and Uniprot Product Information

• NCBI GI #: 15619015
• NCBI GeneID: 5568
• NCBI Accession #: NP_002723.2
• NCBI GenBank Nucleotide #: NP_002723.2
• UniProt Accession #: P22612
• NCBI Official Full Name: cAMP-dependent protein kinase catalytic subunit gamma
• NCBI Official Synonym Full Names: protein kinase cAMP-activated catalytic subunit gamma
• NCBI Official Symbol: PRKACG
• NCBI Official Synonym Symbols: KAPG; PKACg; BDPLT19
• NCBI Protein Information: cAMP-dependent protein kinase catalytic subunit gamma
• UniProt Protein Name: cAMP-dependent protein kinase catalytic subunit gamma
• UniProt Gene Name: PRKACG
• UniProt Synonym Gene Names: PKA C-gamma
• UniProt Entry Name: KAPCG_HUMAN

NCBI Description

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit. [provided by RefSeq, Jul 2008]

Uniprot Description

PKACG: Phosphorylates a large number of substrates in the cytoplasm and the nucleus. A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Testis specific. But important tissues such as brain and ovary have not been analyzed for the content of transcript. Activated by cAMP. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.

Protein type: Kinase, protein; Protein kinase, AGC; EC 2.7.11.11; Protein kinase, Ser/Thr (non-receptor); AGC group; PKA family

Chromosomal Location of Human Ortholog: 9q13

Cellular Component: cytosol

Molecular Function: cAMP-dependent protein kinase activity; ATP binding

Biological Process: epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; water transport; activation of protein kinase A; male gonad development; glucose metabolic process; pathogenesis; signal transduction; protein amino acid phosphorylation; gluconeogenesis; phospholipase C activation; carbohydrate metabolic process; triacylglycerol catabolic process; energy reserve metabolic process; innate immune response; renal water homeostasis; spermatogenesis; blood coagulation; transmembrane transport; regulation of insulin secretion

Disease: Mental Retardation, Autosomal Dominant 31